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Electrospinning
Design, fabrication and characterisation of drug-loaded vaginal films: State-of-the-art
Highlights
• Film technology provides platforms adaptable to the desired drug release profile.
• Several natural and synthetic polymers have been considered to obtain vaginal films.
• Plasticisers and other excipients allow modifying the relevant properties of films.
• Solvent…
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Electrospun Solid Formulation of Anaerobic Gut Microbiome Bacteria
A model anaerobic bacterium strain from the gut microbiome (Clostridium butyricum) producing anti-inflammatory molecules was incorporated into polymer-free fibers of a water-soluble cyclodextrin matrix (HP-β-CD) using a promising scaled-up nanotechnology, high-speed electrospinning. A long-term…
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Progress in the design and development of “fast-dissolving” electrospun nanofibers based drug…
Electrospinning has emerged as most viable approach for the fabrication of nanofibers with several beneficial features that are essential to various applications ranging from environment to biomedicine. The electrospun nanofiber based drug delivery systems have shown tremendous advancements over the…
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Electrospun tri-layer nanodepots for sustained release of acyclovir
New strategies based on complex nanostructures for developing advanced functional materials providing sustained release of loaded active ingredients are highly desired in various scientific fields. In the present study, a new strategy was proposed to prepare a trilayer nanodepot, in which a drug…
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Fabrication of Polylactic Acid/Paclitaxel Nano Fibers by Electrospinning for Cancer Therapeutics
Background: Polylactic acid (PLA) is a thermoplastic and biodegradable polyester, largely derived from renewable resources such as corn starch, cassava starch and sugarcane. However, PLA is only soluble in a narrow range of solvents such as tetrahydrofuran, dioxane, chlorinated solvents and heated…
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Human mouthfeel panel investigating the acceptability of electrospun and solvent cast orodispersible…
A human panel study was performed to investigate the acceptability of orodispersible electrospun and solvent cast films. 50 healthy volunteers took two drug-free samples of polyvinyl alcohol films prepared by the two methods. On a 5-point hedonic scale, the volunteers assessed the films’ perceived…
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Hypromellose – A traditional pharmaceutical excipient with modern applications in oral and…
Hydroxypropylmethylcellulose (HPMC), also known as Hypromellose, is a traditional pharmaceutical excipient widely exploited in oral sustained drug release matrix systems. The choice of numerous viscosity grades and molecular weights available from different manufacturers provides a great variability…
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Electrospun cellulose acetate/gelatin nanofibrous wound dressing containing berberine for diabetic…
Functional wound dressing with tailored physicochemical and biological properties is vital for diabetic foot ulcer (DFU) treatment. Our main objective in the current study was to fabricate Cellulose Acetate/Gelatin (CA/Gel) electrospun mat loaded with berberine (Beri) as the DFU-specific wound…
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Electrospun Orodispersible Films of Isoniazid for Pediatric Tuberculosis Treatment
Child-appropriate dosage forms are critical in promoting adherence and effective pharmacotherapy in pediatric patients, especially those undergoing long-term treatment in low-resource settings. The present study aimed to develop orodispersible films (ODFs) for isoniazid administration to children…
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Electrospinning of natural polymers for the production of nanofibres for wound healing applications
Wound healing is a highly regulated process composed of four overlapping phases: (1) coagulation/haemostasis, (2) inflammation, (3) proliferation and (4) remodelling. Comorbidities such as advanced age, diabetes and obesity can impair natural tissue repair, rendering the wound in a pathological…
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