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Electrospinning
Poly (Lactic Acid) Nano-fibers as Drug-delivery Systems
Numerous Scientists have discovered the procedure of nano-technology, explicitly nano-fibers, as drug-delivery systems for trans-dermal uses.
Nano-fibers can be used to deliver drugs and are capable of controlled-release for a continued period of time. Poly (Lactic Acid) (PLA) is the lastly…
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Continuous drying of a protein-type drug using scaled-up fiber formation with HP-β-CD matrix…
The goals of this work were to evaluate if high-speed electrospinning can be used as a gentle and continuous drying technology to produce protein-containing cyclodextrin-based fibers from an aqueous solution and to convert the produced protein-cyclodextrin fibers into a directly compressible powder.…
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Quasi-Dynamic Dissolution of Electrospun Polymeric Nanofibers Loaded with Piroxicam
We investigated and monitored in situ the wetting and dissolution properties of polymeric nanofibers and determined the solid-state of a drug during dissolution. Piroxicam (PRX) was used as a low-dose and poorly-soluble model drug, and hydroxypropyl methylcellulose (HPMC) and polydextrose (PD) were…
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Formulation and Characterization of Aceclofenac-Loaded Nanofiber Based Orally Dissolving Webs
Aceclofenac-loaded poly(vinyl-pyrrolidone)-based nanofiber formulations were prepared by electrospinning to obtain drug-loaded orally disintegrating webs to enhance the solubility and dissolution rate of the poorly soluble anti-inflammatory active that belongs to the BCS Class-II.…
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Pharmaceutical applications of electrospinning
Development of tailor-made pharmaceutical nanofibers has gained vital prominence due to ease of fabrication and versatility of electrospinning (ES).
ES is one of the flexible and, wonderful strategies for the fabrication of nanofibers. ES unit comprises a supplier of high voltage current, a…
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Monitoring of Antimicrobial Drug Chloramphenicol Release from Electrospun Nano- and Microfiber Mats…
New strategies are continuously sought for the treatment of skin and wound infections due to increased problems with non-healing wounds. Electrospun nanofiber mats with antibacterial agents as drug delivery systems provide opportunities for the eradication of bacterial infections as well as wound…
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Comparison of Traditional and Ultrasound-Enhanced Electrospinning in Fabricating Nanofibrous Drug…
We investigated nozzleless ultrasound-enhanced electrospinning (USES) as means to generate nanofibrous drug delivery systems (DDSs) for pharmaceutical and biomedical applications. Traditional electrospinning (TES) equipped with a conventional spinneret was used as a reference method.…
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Preformulation Study of Electrospun Haemanthamine-Loaded Amphiphilic Nanofibers Intended for a Solid…
Haemanthamine (HAE) has been proven as a potential anticancer agent. However, the therapeutic use of this plant-origin alkaloid to date is limited due to the chemical instability and poorly water-soluble characteristics of the agent. To overcome these challenges, we developed novel amphiphilic…
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Electrospun amorphous solid dispersions of meloxicam: Influence of polymer type and downstream…
The objectives of this work were to develop meloxicam based amorphous solid dispersion through electrospinning technique and evaluate the effect of the polymeric matrix on the physicochemical properties of the fibers and the downstream processing ability to orodispersible dosage forms.
Drug –…
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Electrospun oral formulations for combined photo-chemotherapy of colon cancer
In this work, we report new formulations for the combined photo-chemotherapy of colon cancer.
Fibers were fabricated via coaxial-electrospinning with the intent of targeting delivery of the anti-cancer drug carmofur (CAR) and the photosensitizer rose bengal (RB) selectively to the colon site. The…
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