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Electrospinning
Electrospinning Optimization of Eudragit E PO with and without Chlorpheniramine Maleate Using a…
Electrospinning is increasingly becoming a viable means of producing drug delivery vehicles for oral delivery, particularly as issues of manufacturing scalability are being addressed. In this study, electrospinning is explored as a taste-masking manufacturing technology for bitter drugs.
The…
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Biomedical Applications of Electrospun Nanofibers: Drug and Nanoparticle Delivery
The electrospinning process has gained popularity due to its ease of use, simplicity and
diverse applications. The properties of electrospun fibers can be controlled by modifying either
process variables (e.g., applied voltage, solution flow rate, and distance between charged capillary
and…
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Electrospinning of Cyclodextrin Functional Nanofibers for Drug Delivery Applications
Electrospun nanofibers have sparked tremendous attention in drug delivery since they can
offer high specific surface area, tailored release of drugs, controlled surface chemistry for preferred
protein adsorption, and tunable porosity. Several functional motifs were incorporated into electrospun…
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Engineering of Nanofibrous Amorphous and Crystalline Solid Dispersions for Oral Drug Delivery
Poor aqueous solubility (<0.1 mg/mL) affects a significant number of drugs currently
on the market or under development. Several formulation strategies including salt formation,
particle size reduction, and solid dispersion approaches have been employed with varied success.
In this review, we…
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Development of A New Delivery System Based on Drug-Loadable Electrospun Nanofibers for Psoriasis…
Psoriasis is a chronic autoimmune systemic disease with an approximate incidence of 2%
worldwide; it is commonly characterized by squamous lesions on the skin that present the typical
pain, stinging, and bleeding associated with an inflammatory response. In this work, poly(methyl
vinyl…
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Fast Dissolving of Ferulic Acid via Electrospun Ternary Amorphous Composites Produced by a Coaxial…
Enhancing the dissolution of insoluble active ingredients comprises one of the most
important issues in the pharmaceutical and biomaterial fields. Here, a third generation solid
dispersion (3rd SD) of ferulic acid was designed and fabricated by a modified coaxial electrospinning
process.
A…
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The Effect of Molecular Properties on Active Ingredient Release from Electrospun Eudragit Fibers
The formation of nanoscale fibers from pH-sensitive polymers is a route which has been widely explored for targeted drug delivery. In particular, the Eudragit L100 and S100 families of polymers have received significant attention for this purpose.
However, while in some cases it is shown that…
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Homogenization of Amorphous Solid Dispersions Prepared by Electrospinning in Low-Dose Tablet…
Low-dose tablet formulations were produced with excellent homogeneity based on drug-loaded electrospun fibers prepared by single-needle as well as scaled-up electrospinning (SNES and HSES). Carvedilol (CAR), a BCS II class compound, served as the model drug while poly (vinylpyrrolidone-co-vinyl…
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Electrospun fibers as potential carrier systems for enhanced drug release of perphenazine
17. July 2016
Abstract
Solubility represents an important challenge for formulation of drugs, because the therapeutic efficacy of a drug depends on the bioavailability and ultimately on its solubility. Low aqueous solubility is one of the main issues related with formulation design…
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