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Electrospinning
Nano-and Microfabrication Techniques in Drug Delivery – Part 1
Nano-and Microfabrication Techniques in Drug Delivery
See the new book, edited by Dimitrios Lamprou. It brings together technical, clinical, regulatory and industrial perspectives. It provides future prospective and includes the potential clinical applications of nano/microfabrication technologies.…
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Technological Aspects and Evaluation Methods for Polymer Matrices as Dental Drug Carriers
he development of polymer matrices as dental drug carriers takes into account the following technological aspects of the developed formulations: the composition and the technology used to manufacture them, which affect the properties of the carriers, as well as the testing methods for assessing…
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Soluplus as a solubilizing excipient for poorly water-soluble drugs: Recent advances in formulation…
Since the emergence of Soluplus® (SOL) as a commercial graft copolymer, multiple publications have been issued on its promising potential as a solubilizing excipient that could promote the dissolution rate and bioavailability of several poorly water-soluble drugs. Numerous drug formulation…
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Development of Imeglimin Electrospun Nanofibers as a Potential Buccal Antidiabetic Therapeutic…
The prevalence of type 2 diabetes (T2D) has been growing worldwide; hence, safe and effective antidiabetics are critically warranted. Recently, imeglimin, a novel tetrahydrotriazene compound, has been approved for use in T2D patients in Japan. It has shown promising glucose-lowering properties by…
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Electrospun HPMC/PEO-blend orodispersible films: how slight batch differences affect the crucial…
Orodispersible films comprise a promising dosage form with a wide range of advantages compared to conventional formulations. The electrospinning process can significantly enhance the relevant characteristics of orodispersible films, e.g., the dissolution rate and the ease of administration. This…
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Preparation and Evaluation of Core–Shell Nanofibers Electrospun from PEU and PCL Blends via a…
The core–shell structured nanofibers are routinely fabricated by coaxial solution and single-nozzle emulsion electrospinning of two polymers. Herein, the core–shell structured polymeric nanofibers were electrospun from mixed solutions of poly(ether urethane) (PEU) with poly(ε-caprolactone) (PCL) or…
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Super disintegrating oromucosal nanofiber patch of zolmitriptan for rapid delivery and efficient…
Oromucosal administration of zolmitriptan using electrospun nanofiber can potentially result in blood plasma concentrations analogous to intravenous kinetics and targeting the brain due to anatomical features of the delivery site. Herein, we report the optimization of zolmitriptan and…
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Preparation and evaluation of astaxanthin-loaded 2-hydroxypropyl-beta-cyclodextrin and Soluplus®…
Abstract
Background
Astaxanthin is a type of food-derived active ingredient with antioxidant, antidiabetic and non-toxicity functions, but its poor solubility and low bioavailability hinder further application in food industry. In the present study, through inclusion technologies, micellar…
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Oligonucleotide Formulations Prepared by High-Speed Electrospinning: Maximizing Loading and…
The aim of this study was to develop antisense oligonucleotide tablet formulations using high-speed electrospinning. Hydroxypropyl-beta-cyclodextrin (HPβCD) was used as a stabilizer and as an electrospinning matrix. In order to optimize the morphology of the fibers, electrospinning of various…
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Electrospun nanofibres in drug delivery: advances in controlled release strategies
Emerging drug-delivery systems demand a controlled or programmable or sustained release of drug molecules to improve therapeutic efficacy and patient compliance. Such systems have been heavily investigated as they offer safe, accurate, and quality treatment for numerous diseases. Amongst newly…
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