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Electrospinning
Physico-chemical analysis of electrospun fibers – A systematic approach
Electrospun fibers emerged as promising drug delivery systems for various pharmaceutical applications due to their favorable properties. However, while for established drug delivery systems (e.g. tablets or capsules) standardized analytical procedures exist, the methodologies for characterization of…
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Electrospun poly(ω-pentadecalactone-co-ε-caprolactone)/gelatin/chitosan ternary nanofibers with…
In recent years, there is an increasing attention on biocompatible electrospun nanofibers for drug delivery applications since they provide high surface area, controlled and sustained drug release, and they mimic the extracellular matrix. In the present study, tetracycline hydrochloride (TCH)…
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Preparation and Functional Evaluation of Electrospun Polymeric Nanofibers as a New System for…
Due to the rapid clearance of external agents from the surface of the cornea, conventional ocular formulations usually require frequent and long duration of administration to achieve a therapeutic level of the drug on the cornea which can be conquered using prolonged-release nanofibrous inserts. In…
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Design and physico-mechanical evaluation of fast-dissolving valsartan polymeric drug delivery system…
Objective(s): Chronic hypertension is a pervasive morbidity and the leading risk factor for cardiovascular diseases. Valsartan, as an antihypertensive drug, has low solubility and bioavailability. The application of orodispersible films of valsartan is suggested to improve its bioavailability. With…
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Production and Characterization of Cellulose Nanofiber Slurries and Sheets for Biomedical…
Cellulose nanomaterials are produced employing a multitude of methodologies including electrospinning, bacterial generation, acid digestion, and a variety of mechanical defibrillation techniques; the morphology of the nanomaterial produced is specific to the production process. Feedstocks range from…
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Development of fast-dissolving dosage forms of curcuminoids by electrospinning for potential tumor…
Curcuminoids (CUs) of antitumor and various other potential biological activities have extremely low water solubility therefore special formulation was elaborated. New fast dissolving reconstitution dosage forms of four CUs were prepared as fibrous form of 2-hydroxypropyl-β-cyclodextin (HP-β-CD). In…
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Emulsion-electrospun polyvinyl alcohol nanofibers as a solid dispersion system to improve solubility…
We attempted to improve the solubility of poorly water-soluble drugs by preparing drug-loaded polyvinyl alcohol (PVA) nanofibers as a solid dispersion system via emulsion electrospinning. Probucol (PBC), a poorly water-soluble drug, was used as a model drug. Nanofibers were electrospun using an…
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Tableted hydrophilic electrospun nanofibers to promote meloxicam dissolution rate
This study investigated the ability of hydrophilic electrospun nanofibers to enhance the dissolution rate of poorly soluble drug Meloxicam (MLX). The drug was loaded into polyvinylpyrrolidone (PVP), polyvinyl caprolactam–polyvinyl acetate–polyethylene glycol (Soluplus®), sodium lauryl sulfate (SLS)…
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Utilising Co-Axial Electrospinning as a Taste-Masking Technology for Paediatric Drug Delivery
The present study describes the use of two taste-masking polymers to fabricate a formulation of chlorpheniramine maleate for paediatric administration. Co-axial electrospinning was utilized to create layered nanofibres; the two polymers, Eudragit® E PO and Kollicoat® Smartseal, were alternated…
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Biocompatibility studies of polyurethane electrospun membranes based on arginine as chain extender
Electrospun polymers are an example of multi-functional biomaterials that improve the material-cellular interaction and aimed at enhancing wound healing. The main objective of this work is to fabricate electrospun polyurethane membranes using arginine as chain extender (PUUR) in order to test the…
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