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Electrospinning
Biopolymer-based nanoparticles with tunable mucoadhesivity efficiently deliver therapeutics across…
To overcome the natural barriers of the ocular system that limit the topical delivery of therapeutically active molecules to the posterior eye, nanoscale drug carriers can be used to improve transcorneal drug transport. So far, using mucoadhesive drug carriers has been put forward as the most…
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Electrospinning for healthcare: recent advancements
Electrospinning is a simple route to generate polymer-based fibres with diameters on the nano- to micron-scale. It has been very widely explored in biomedical science for applications including drug delivery systems, diagnostic imaging, theranostics, and tissue engineering. This extensive literature…
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Fabrication of carboxymethyl chitosan/poly(ε-caprolactone)/doxorubicin/nickel ferrite core-shell…
The coaxial electrospinning for producing core-shell nanofibers due to control the release profile of drug by the shell layer has been developed. N-carboxymethyl chitosan (CMC)-polyvinyl alcohol (core)/poly(ε-caprolactone) (PCL) (shell) nanofibers were produced via coaxial electrospinning.…
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Capability of core-sheath polyvinyl alcohol- Polycaprolactone emulsion electrospun nanofibrous…
Core-sheath nanofibrous scaffolds from polyvinyl alcohol (PVA)-strontium ranelate (SrR)- Polycaprolactone (PCL) were prepared by water in oil electrospinning method. Thus, PCL (the oil phase) was used as the shell part and a mixture of PVA and SrR (the water phase) was inserted in the core.
The…
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Development of Water-Soluble Electrospun Fibers for the Oral Delivery of Cannabinoids
Cannabidiol (CBD) and cannabigerol (CBG) are two active pharmaceutical ingredients, derived from cannabis plant. In the present study, CBD and CBG were formulated with polyvinyl(pyrrolidone) (PVP) and Eudragit L-100, using electrohydrodynamic atomization (electrospinning).
The produced fibers…
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Comparison of Amorphous Solid Dispersions of Spironolactone Prepared by Spray Drying and…
This research aimed to compare two solvent-based methods for the preparation of amorphous solid dispersions (ASDs) made up of poorly soluble spironolactone and poly(vinylpyrrolidone-co-vinyl acetate). The same apparatus was used to produce, in continuous mode, drug-loaded electrospun (ES) and…
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Pharmaceutical applications of aqueous scaled-up electrospinning
Thesis findings
A solid formulation of a model biopharmaceutical drug (β-galactosidase) was developed and produced by high-speed electrospinning for the first time. A fully aqueous polymeric solution was successfully electrospun with a 30 mL/h feeding rate, which is about 30x higher than the…
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Electrospraying as a novel method of particle engineering for drug delivery vehicles
Encapsulation technologies can be used to preserve therapeutic and bioactive compounds from harsh conditions (e.g., light, moisture, and oxygen) and biological destruction (enzymes, metabolism, and phagocytosis). Encapsulation involves the incorporation of the active moieties into a shell structure…
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Energy-Saving Electrospinning with a Concentric Teflon-Core Rod Spinneret to Create Medicated…
Although electrospun nanofibers are expanding their potential commercial applications in various fields, the issue of energy savings, which are important for cost reduction and technological feasibility, has received little attention to date. In this study, a concentric spinneret with a solid…
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Developing and scaling up fast-dissolving electrospun formulations based on poly(vinylpyrrolidone)…
Poly(vinyl pyrrolidone) (PVP) electrospun fibers loaded with ketoprofen were fabricated in this work as potential fast dissolving drug delivery systems (DDSs) for oral delivery. By changing the processing parameters and collector geometry it was possible to increase the throughput rate from 1 to 20…
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