Continuous drying of a protein-type drug using scaled-up fiber formation with HP-β-CD matrix resulting in a directly compressible powder for tableting
The goals of this work were to evaluate if high-speed electrospinning can be used as a gentle and continuous drying technology to produce protein-containing cyclodextrin-based fibers from an aqueous solution and to convert the produced protein-cyclodextrin fibers into a directly compressible powder.
A 400 mL/h feeding rate was used during the electrospinning experiments, corresponding to a ∼270 g/h production rate of the dried material. The produced fibers were collected in a cyclone. The fibers were found grindable without secondary drying, and the ground powder was mixed with tableting excipients and was successfully tableted by direct compression.
The model protein-type drug (β-galactosidase) remained stable during each of the processing steps (electrospinning, grinding, tableting) and after 6 months of storage at room temperature in the tablets. The obtained results demonstrate that high-speed electrospinning can be a gentle alternative to traditional drying methods used for protein-type drugs, and that tablet formulation is achievable from the electrospun material prepared this way.
Author links open overlay panelPannaVass, Zsombor K.Nagy, RitaKóczián, CsabaFehér, BalázsDémuth, EdinaSzabó, Sune K.Andersen, TamásVigh, GeertVerreck, IstvánCsontos, GyörgyMarosi, EditHirsch
https://doi.org/10.1016/j.ejps.2019.105089
