Pharma Excipients
Emulsifier
Intranasal delivery of insulin by self-emulsified nanoemulsion system: In vitro and in vivo studies
The main objective of this research was to develop a self-emulsified nanoemulsion (SEN) dosage form of insulin where insulin is loaded into the lipid phase of the nanoemulsion for enhanced absorption through intranasal delivery. When loaded into the lipid droplets (oil phase), insulin can be…
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Improved anti-inflammatory effect of curcumin by designing self-emulsifying drug delivery system
The purpose of the present study was to prepare and evaluate self-emulsifying drug delivery system (SEDDS) of curcumin (Cur) to enhance its solubility and percentage release for the evaluation of anti-inflammatory effect. Curcumin loaded SEDDS formulation was prepared, and zones of…
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Application of Vitamin E TPGS in ocular therapeutics – Attributes beyond excipient
Diseases affecting the anterior segment and the external surface of the eye are usually treated by drugs applied topically. The formulations designed for this purpose are developed to deliver active pharmaceutical agents to the eye optimally. These formulations are prepared by adding various agents…
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Self-emulsification in chemical and pharmaceutical technologies
The interest in the low energy self-emulsification techniques has exploded in the recent years, driven by three main trends: by the transition to “greener” technologies in both its aspects – less energy consumption and replacement of the petrochemicals by natural ingredients; by the costly and…
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QbD Approach towards Robust Design Space for Flutamide/Piperine Self-Emulsifying Drug Delivery…
Flutamide which is used to treat prostate cancer and other diseases induces liver damage during and after the therapy. The aim of this study was to develop a flutamide/piperineco-loaded self-emulsifying drug delivery system (FPSEDDS) to inhibit flutamide-induced liver injury by utilizing piperine as…
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Oral delivery of therapeutic peptides and proteins: Technology landscape of lipid-based nanocarriers
The oral administration of therapeutic peptides and proteins is favoured from a patient and commercial point of view. In order to reach the systemic circulation after oral administration, these drugs have to overcome numerous barriers including the enzymatic, sulfhydryl, mucus and epithelial…
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A Customized Screening Tool Approach for the Development of a Self-Nanoemulsifying Drug Delivery…
The present study focused on establishing a novel, (pre-)screening approach that enables the development of promising performing self-nanoemulsifying drug delivery systems (SNEDDSs) with a limited number of experiments. The strategic approach was based on first identifying appropriate excipients…
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Lecithin-based nanoemulsions of traditional herbal wound healing agents and their effect on human…
In previous studies, lecithin-based nanoemulsions (NEs) have been shown to be skin friendly drug carrier systems. Due to their nontoxic properties, NEs might also be suitable as wound healing agents. Hence, different O/W NEs based on lecithin Lipoid® S 75 and plant oils or medium chain triglycerides…
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Self-nanoemulsifying composition containing curcumin, quercetin, Ganoderma lucidum extract powder…
Liquid self-nanoemulsifying drug delivery system (L-SNEDDS) of curcumin and quercetin were prepared by dissolving them in isotropic mixture of Labrafil M1944CS®, Capmul MCM®, Tween-80® and Transcutol P®. The prepared L-SNEDDS were solidified using Ganoderma lucidum extract, probiotics and…
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Plant-Derived Saponins: A Review of Their Surfactant Properties and Applications
In response to increasing natural surfactant demand and environmental concerns, natural plant-based surfactants have been replacing synthetic ones. Saponins belong to a class of plant metabolites with surfactant properties that are widely distributed in nature. They are eco-friendly because of their…
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