Pharma Excipients
Emulsifier
Pullulan film incorporated with nanocapsules improves pomegranate seed oil anti-inflammatory and…
This study aimed to prepare pullulan films containing pomegranate seeds oil (PSO) based nanocapsules, and evaluate the formulation efficacy in the treatment of atopic dermatitis (AD)-like lesions induced by 2,4-dinitrochlorobenzene (DNCB). The Eudragit RS 100® nanocapsules (PSONC) were prepared by…
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Floating microspheres of Miglitol as gastro retentive drug delivery system: 32 full factorial design…
Background:
The goal of this study was to develop a gastro retentive floating drug delivery system that would improve site specific activity, patient compliance and therapeutic efficacy.
Methodology:
Floating microspheres of Miglitol were formulated by double emulsion method using ethyl cellulose…
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Phospholipids – Nature’s Versatile All-Rounders Showing Excellent Tolerability
Phospholipids (PLs) are essential building blocks of all biological membranes exhibiting a huge variety of functions. They play an essential role in the natural digestive process of food and are excreted as component of bile by the liver. Bile emulsifies fatty food components which enhances their…
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Formulation and assessment of hydroxyzine HCL solid lipid nanoparticles by dual emulsification…
Hydroxyzine HCL (HHCL) is an antihistamine, used for the treatment of allergic skin conditions. The purpose of this study was to achieve a dual phase drug delivery rate across the intact skin, to enhance HHCL permeation through the stratum corneum, to assess the peripheral H1-antihistaminic activity…
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Self-dispersing self-assembling systems for controlled oral delivery of gliclazide
Self-microemulsifying systems undergo self-dispersion to form microemulsion with subsequent self-assembly to form liquid crystalline (LC) and/or gel phases. These transitions modulate the release and absorption pattern of loaded drug. Accordingly, the primary objective was to evaluate these phases…
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Production of lipophilic nanogels by spontaneous emulsification
Nanosized gel particles, so-called nanogels, have attracted substantial interest in different application fields, thanks to their controllable and three-dimensional physical structure, good mechanical properties and potential biocompatibility. Literature reports many technologies for their…
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Solid self emulsifying drug delivery system: Superior mode for oral delivery of hydrophobic cargos
A significant proportion of recently approved drug molecules possess poor aqueous solubility which further restrains their desired bioavailability. Poor aqueous solubility of these drugs poses significant hurdles in development of novel drug delivery systems and achieving target response.…
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Quality by Design Methodology Applied to Process Optimization and Scale up of Curcumin Nanoemulsions…
In the presented study, we report development of a stable, scalable, and high-quality curcumin-loaded oil/water (o/w) nanoemulsion manufactured by concentration-mediated catastrophic phase inversion as a low energy nanoemulsification strategy. A design of experiments (DoE) was constructed to…
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SIMALINE™ L80 – Liquid emulsifier for Geltrap™ “Gel-in-oil” and traditional W/O emulsion from…
The value proposition for formulation scientists is:
A novel Gel-in-oil dosage form (Geltrap™) based on regulatory-approved excipients
Able to stabilize high quantities of solvents to solubilize & delivers APIs, thanks to Sepineo polymers
A texture optimal for patient compliance…
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Maximizing the Oral Bioavailability of Poorly Water-Soluble Drugs Using Novel Oil-Like Materials in…
Lipid-based formulations, such as self-microemulsifying drug-delivery systems (SMEDDSs), are promising tools for the oral delivery of poorly water-soluble drugs. However, failure to maintain adequate aqueous solubility after coming into contact with gastrointestinal fluids is a major drawback.
In…
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