Pharma Excipients
Emulsifier
Self-Nano-Emulsifying Drug-Delivery Systems: From the Development to the Current Applications and…
Approximately one third of newly discovered drug molecules show insufficient water solubility and therefore low oral bio-availability. Self-nano-emulsifying drug-delivery systems (SNEDDSs) are one of the emerging strategies developed to tackle the issues associated with their oral delivery. SNEDDSs…
Read More...
Read More...
Quality by design (QbD) optimization of diazepam-loaded nanostructured lipid carriers (NLC) for…
Diazepam is commonly used in the management of epileptic seizures, although it has limitations that can be overcome by using formulations that are easier to administer and capable of directing the drug to the brain. In this field, it has been reported that the use of nanostructured lipid carriers…
Read More...
Read More...
New potential application of hydroxypropyl-β-cyclodextrin in solid self-nanoemulsifying drug…
The purpose of this study was to use hydroxypropyl-β-cyclodextrin (HP-β-CD) as a novel carrier in solid SNEDDS and solid dispersions to enhance the solubility and oral bioavailability of poorly water-soluble dexibuprofen. The novel dexibuprofen-loaded solid SNEDDS was composed of dexibuprofen,…
Read More...
Read More...
Self-emulsifying formulations to augment therapeutic efficacy of nutraceuticals: From concepts to…
Background
Nutraceuticals often referred as medicinally or nutritionally functional foods has drawn extensive attention in recent years because of their wide array of pharmacological activities. It has been well established that the consumption of nutraceuticals is consistently linked with…
Read More...
Read More...
Dual-Acting Zeta-Potential-Changing Micelles for Optimal Mucus Diffusion and Enhanced Cellular…
Context: Overcoming the intestinal mucosal barrier can be a challenge in drug delivery. Nanoemulsions with negative zeta potentials can effectively permeate the mucus layer, but those with positive zeta potentials are better taken up by cells; a nanoemulsion with capricious zeta potential from…
Read More...
Read More...
Encapsulation of phenolic compounds within nano/microemulsion systems: A review
Phenolic compounds (phenolics) have received great attention in the food, pharmaceutical and nutraceutical industries due to their health-promoting attributes. However, their extensive use is limited mainly due to their poor water dispersibility and instability under both processing conditions…
Read More...
Read More...
Emulsification Speed of Amphiphilic Starches
Amphiphilic starches (sodium octenylsuccinate starches) are a well‐known emulsifier for various food and pharma applications. Typical applications are the encapsulation of lipophilic compounds such as vitamins and other micronutrients or the direct or indirect solubilization of drug substances . To…
Read More...
Read More...
GE11 Modified PLGA/TPGS Nanoparticles Targeting Delivery of Salinomycin to Breast Cancer Cells
Abstract:
Salinomycin (Sal) is a potent inhibitor with effective anti-breast cancer properties in clinical therapy. The occurrence of various side effect of Sal greatly limits its application. The epidermal growth factor receptor (EGFR) family is a family of receptors highly expressed in most…
Read More...
Read More...
Tefose® 63 – A nonionic oil-in-water emulsifier for topical formulations
Tefose® 63 is a physical mixture of three components: PEG-6 palmitostearate, ethylene glycol palmitostearate and PEG-32 palmitostearate. The exact quantity of each component has been carefully selected to obtain a self-emulsifying base.
GET TEFOSE® 63 HERE
Tefose® 63 is a non-ionic…
Read More...
Read More...
Removal of azithromycin from aqueous bulk solution using water/ethanol/transcutol/capryol-90 green…
The present work aimed to remove azithromycin (AZM) from contaminated aqueous system using a water/ethanol/transcutol/capryol-90 green nanoemulsion. The drug is identified as potential pharmaceutical drug for detrimental effect on flora and fauna of aquatic lives and human health. Green…
Read More...
Read More...