Pharma Excipients
Emulsifier
Preparation and Evaluation of Mebendazole Microemulsion for Intranasal Delivery: an Alternative…
Although mebendazole (MBZ) has demonstrated antitumor activity in glioblastoma models, the drug has low aqueous solubility and therefore is poorly absorbed. Considering that other strategies are needed to improve its bioavailability, the current study was aimed to develop and evaluate novel…
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Development and Optimization of Naringenin-Loaded Chitosan-Coated Nanoemulsion for Topical Therapy…
The potential role of naringenin (NAR), a natural flavonoid, in the treatment of chronic wound has prompted the present research to deliver the drug in nanoemulsion (NE) form, where synergistic role of chitosan was achieved through development of chitosan-coated NAR NE (CNNE). The NE consisted of…
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Cellulose and its derivatives for application in 3D printing of pharmaceuticals
Background
Three-dimensional printing (3DP) has emerged as an advanced manufacturing technology capable of producing complex yet precise medicines intended for patient-centric drug therapy. However, printable materials currently available for 3DP are far too limited.
Area covered
The current…
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Film forming systems for topical and transdermal drug delivery
Methyl ester derivatives of alginic acid have been evaluated as potential multifunctional excipients for pharmaceutical direct compression. The use of alginic acid as an excipient in tablet formulation is limited because of certain drawbacks such as low tablet hardness and poor compressibility. The…
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Evaluating drug distribution and release in ophthalmic emulsions: Impact of release conditions
The purpose of this study is to investigate the process of drug distribution and mechanism of drug release of ophthalmic emulsions in the context of factors associated with the drug release. Cyclosporine and difluprednate emulsions were chosen as model systems.
Highlights
• The process of…
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Microemulsion assisted transdermal delivery of a hydrophilic anti-osteoporotic drug: Formulation, in…
Gastrointestinal adverse effects such as esophageal irritation and ulcers are the major disadvantages of the oral administration of alendronate (ALD) and nitrogen-containing bisphosphonate. We hypothesized that the transdermal delivery of ALD via water in oil (w/o) microemulsion might help to…
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A Solid Ultra Fine Self-Nanoemulsifying Drug Delivery System (S-SNEDDS) of Deferasirox for Improved…
The research work was designed to develop a solid self-nanoemulsifying drug delivery system (S-SNEDDS) of deferasirox (DFX). According to the solubility studies of DFX in different components, Peceol, Kolliphor EL, and Transcutol were selected as excipients. Pseudo-ternary phase diagrams were…
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Essential oils: a review on their salient biological activities and major delivery strategies
Essential oils are volatile, complex products of plants as secondary metabolites and include terpenes and their oxygenated derivatives, such as alcohols, aldehydes, esters, ketones, phenols and oxides. In recent years, out of 3000 essential oils obtained from plant origin only 300 essential oils…
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Hierarchical mesoporous silica templated by the combination of fine emulsion and micelles
Highlights
• Mixed Organized Molecular Systems are formed by the mixture of Kolliphor and P123 templates.
• Hierarchical mesoporous silicas obtained by combining fine emulsion and micelles.
• Porosity features controlled by the weight.
• Ratios between fine emulsion and P123…
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Percutaneous delivery of levetiracetam as an alternative to topical nonsteroidal anti-inflammatory…
The study focused on formulation of carmellose sodium hydrogels and nonionic microemulsions with 5% and 10% of levetiracetam and investigation of drug concentration influence on their physicochemical characteristics and in-use stability as well as influence of drug concentration and carrier type on…
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