Pharma Excipients
Emulsifier
Residual film formation after emulsion application: understanding the role and fate of excipients on…
This study focuses on the fate of excipients contained in topical emulsions once applied on the skin. The aim was thus to develop a methodology to characterize the residue left on the skin shortly after emulsion application. To this end, both the role and the impact of the different excipients on…
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Enhancing in vivo oral bioavailability of cajaninstilbene acid using UDP-glucuronosyl transferase…
Cajaninstilbene acid (CSA) exerts wide pharmacological activities, such as anti-inflammation, hypoglycaemic activity, analgesic effect and cognition improvement. However, it underwent severe phase II metabolism mediated by UDP-glucuronosyltransferase (UGT) in the gastrointestinal (GI) tract after…
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Pickering nano-emulsions stabilized by Eudragit RL100 nanoparticles as oral drug delivery system for…
The purpose of this study was to develop Pickering water-in-oil nano-emulsions only stabilized by Eudragit RL100 nanoparticles (NPs), in order to increase the nano-emulsion stability and create a barrier to improve the drug encapsulation and better control the drug release. The first part of this…
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Engineering oral delivery of hydrophobic bioactives in real-world scenarios
Bioactive compounds, often hydrophobic in nature, tend to degrade during processing outside or inside the body with rapid clearance rates, resulting in poor bioavailability. In this review, we survey recent scientific advances in lipid-based colloidal delivery systems (conventional…
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Bioactive Self-Nanoemulsifying Drug Delivery Systems (Bio-SNEDDS) for Combined Oral Delivery of…
Abstract
Background: Bioactive oils of natural origin have gained huge interests from health care professionals and patients.
Objective: To design a bioactive self-nanoemulsifying drug delivery system (Bio-SNEDDS) comprising curcumin (CUR) and piperine (PP) by incorporating bioactive natural…
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Development and Optimization of Self-nanoemulsifying Drug Delivery System of Ibrutinib
Objective: The present research demonstrates the formulation of novel self-nanoemulsifying drug delivery system (SNEDDS) for potential delivery of ibrutinib by oral route.
Materials and Methods: Ibrutinib SNEDDS formulation optimized using three-factor, three-level Box–Behnken design and the…
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Design and Development of Darunavir Loaded Self Micro Emulsifying Drug Delivery System using Extreme…
The therapeutic utility of many poorly water-soluble drugs are severely restricted for their bioavailability. The present study was aimed to development of self-micro emulsifying drug delivery (SMEDDS) system for a poorly water soluble anti-retroviral drug - Darunavir by the application of Quality…
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Development and Characterization of Water-in-Oil Microemulsion for Transdermal Delivery of Eperisone…
Background: Eperisone hydrochloride possesses short biological half-life due to first pass metabolism resulting in low bioavailability and short duration of response with toxic effects, ultimately limits its utilization for treatment of muscle spasm.
Objective: In view of this background, current…
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Phosphorylated PEG-emulsifier: Powerful tool for development of zeta potential changing…
Aim
It was the aim of this study to synthesize a phosphorylated emulsifier possessing a PEG-linker for establishment of a potent zeta potential changing system in self-emulsifying drug delivery systems (SEDDS).
Methods
N,N'–Bis(polyoxyethylene)oleylamine (POA) was phosphorylated utilizing…
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Design of self-nanoemulsifying system to enhance absorption and bioavailability of poorly permeable…
The aim of this study was to develop self-nanoemulsifying system (SNES) to improve the oral bioavailability of Aliskiren hemi-fumarate (AF). The solubility of AF in various oils, surfactants and, co-surfactants was studied to select the proper components of the system. The composition of SNES was…
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