Pharma Excipients
Emulsifier
Tefose® 63: Oil-in-water emulsifier for topical dosage forms
A multi-component system
Tefose® 63 is a physical mixture of three components: PEG-6 palmitostearate, ethylene glycol palmitostearate and PEG-32 palmitostearate. The exact quantity of each component has been carefully selected to obtain a self-emulsifying base (Figure1, click to enlarge).…
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Development of a Novel Nanoemulsion Formulation to Improve Intestinal Absorption of Cannabidiol
Cannabidiol (CBD) is highly lipophilic, and its oral bioavailability is known to be very low in humans. In this study, we developed a novel nanoemulsion preparation of CBD (CBD-NE) to improve the poor solubility and absorption of CBD. The pharmacokinetic profiles of CBD in rats were evaluated after…
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Semisolid-filled Capsules of Carvedilol for Improving Dissolution Behaviour
The present investigation was aimed at enhancing the dissolution properties of carvedilol, a poorly water-soluble drug using a combination of solid dispersion and semisolid-filled capsule. The use of lauroyl polyoxyl-6 glycerides as a carrier in a semisolid base to improve the dissolution behaviour…
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Olanzapine, improvement of biopharmaceutical performance in solid dosage form
Olanzapine is an effective antipsychotic drug used for the treatment of positive and negative symptoms of schizophrenia.
It suffers from poor water solubility in addition to extensive first-pass metabolism in the liver to inactive metabolites, resulting in a poor oral bioavailability of nearly…
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Emerging role of nanosuspensions in drug delivery systems
Rapid advancement in drug discovery process is leading to a number of potential new drug candidates having excellent drug efficacy but limited aqueous solubility.
By virtue of the submicron particle size and distinct physicochemical properties, nanosuspension has the potential ability to tackle…
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Phase inversion-based nanoemulsions of medium chain triglyceride as potential drug delivery system…
Lipid nanoemulsions are attractive drug delivery systems for lipophilic drugs.
To produce nanoemulsions with droplets of very small diameter (<100 nm), we investigated thermotropic phase transitions as an alternative to the standard procedure of high-pressure homogenization. Employing shock…
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Dissolution Enhancement of Carbamazepine using Twin-screw Melt Granulation
The current study explored the twin-screw melt granulation (TSMG) as a potential technology for the water solubility enhancement of BCS (biopharmaceutical classification system) class II drugs.
As a model drug, carbamazepine (CBZ) was formulated with three different polymers as melt granules…
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High purity excipients – A Simple Solution to a Complex Problem
A drug-dev.com article by Dr. William Small and Arsalan Khan
It wouldn’t come as a surprise to anyone that active pharmaceutical ingredients (APIs) come in a wide variety. Small molecule, large molecule, peptide, monoclonal antibody, innovative, generic; the list goes on. These molecules have the…
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Prilling of API/fatty acid suspensions: screening of additives for drug release modification
Current study screened additives which could modify the drug release from prills made of an active pharmaceutical ingredient/fatty acid (API/FA) suspension, without negatively influencing the processability and/or stability of the formulation.
Therefore, 11 additives (i.e. emulsifiers,…
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The Optimization Design Of Lactoferrin Loaded HupA Nanoemulsion For Targeted Drug Transport Via…
Huperzine A (HupA) is a selective acetylcholinesterase inhibitor used to treat Alzheimer’s disease. The existing dosage of HupA lacks brain selectivity and can cause serious side effects in the gastrointestinal and peripheral cholinergic systems.
Purpose
The aim of this study was to develop and…
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