Emulsifier

Background Roxithromycin is a macrolide antibiotic included in the biopharmaceutics classification system (BCS) class II with poor water solubility (0.0189 mg/mL) resulting poor solubility of roxithromycin in gastrointestinal track and decreases bioavailability. Technology development of self nano…
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Establishing bioequivalence (BE) of ophthalmic emulsions in the absence of in vivo data is challenging. In these emulsions, drug release is a complex process due to drug distribution among various phases which are difficult to characterize. The objective of this study is to investigate the…
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Topical formulations may be used to deliver active pharmaceutical ingredients (APIs) to or through the skin. These formulations typically possess a relatively soft, spreadable consistency and are often formulated as either water-in-oil or oil-in-water emulsions. BASF offers an unparalleled…
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Self-emulsifying drug delivery systems (SEDDS) are one of the proven methods to increase solubility and bioavailability of poorly soluble drugs. SEDDS are isotropic mixtures, consisting of oils, surfactants, and sometimes cosolvents. Designed formulations are used to improve the oral absorption…
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Vitamin E TPGS, a water soluble derivative of natural Vitamin E, is a multirole excipient for pharmaceutical drug delivery innovation. Vitamin E TPGS is a non-ionic surfactant used as: solubilizer of poorly soluble drugs absorption enhancer emulsifier vehicle for lipid-based drug…
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Onychomycosis is an opportunistic fungal infection often infecting people with compromised immune system. Currently available treatment interventions such as physical, surgical, and chemical‐based approaches are successful in treating the condition, however, are painful and nonpatient complaint.…
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Quercus Suber Bark from Quercus suber L. is a natural, renewable and biodegradable biomaterial with multifunctional proprieties. In this study, we used it as solid particles to stabilize a Pickering emulsion. The main goal was to produce an optimized topical formulation using biocompatible organic…
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Producing stable particle-stabilised emulsions of small droplet sizes and high monodispersity via membrane emulsification approaches is hindered by the poor mixing environment during processing and the low diffusivity and minimal interfacial tension lowering capacity of colloidal particles. The…
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Bioavailability, one of the prime pharmacokinetic properties of a drug, is defined as the fraction of an administered dose of unchanged drug that reaches the systemic circulation and is used to describe the systemic availability of a drug. Bioavailability assessment is imperative in order to…
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Self-dispersing lipid-based formulations, particularly self-microemulsifying drug delivery systems (SMEDDS) have gained an increased interest in recent times as a means to enhance the oral bioavailability of poorly water-soluble lipophilic drugs. Upon dilution, SMEDDS self-emulsify in an aqueous…
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