Pharma Excipients
Emulsifier
The effect of a lipid composition and a surfactant on the characteristics of the solid lipid…
Abstract
Solid lipid microparticles (SLM) were produced by produced by a two-step process that, firstly, involved the emulsification of the molten lipid phase in a heated aqueous phase and, secondly, the system cooling. Compritol 888 ATO and Precirol ATO 5, including their…
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INFLUENCE OF INTERFACIAL AND BULK PROPERTIES OF CELLULOSE ETHERS ON LIPOLYSIS OF OIL-IN-WATER…
12. March 2016
Cellulose ethers are usually used as secondary emulsifiers. Different types of commercial hydroxypropylmethylcellulose (HPMC) have been used here as the main emulsifier of oil-in-water emulsions to probe their impact on the lipid digestibility under simulated…
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Preparation of Fenofibrate Dry Emulsion and Dry Suspension Using Octenyl Succinic Anhydride Starch…
23. December 2015 Purpose of this study was to investigate the ability of octenyl succinic anhydride (OSA) starch as emulsifier and solid carrier in dry emulsion (DE) and dry suspension (DS) formulations. Fenofibrate (FF) was…
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Improved oral absorption of tacrolimus by a solid dispersion with hypromellose and sodium lauryl…
06. December 2015 A novel surfactant-incorporated hydroxypropyl methylcellulose (HPMC) solid dispersion (SD) system was constructed in order to facilitate the release rate and oral absorption of tacrolimus (FK506), a poorly…
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The central role of excipients in drug formulation
Active substances are rarely administered alone. For example, levothyroxine, a synthetic form of the thyroid hormone, indicated in the treatment of hypothyroidism, is administered at a very low dosage, ranging from 15 μg to 200 μg. These very small amounts of powder mean that it is not possible…
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Drug-Excipient Compatibility for the Formulation Development of Solid Lipid Nanoparticles
14. September 2015 Solid lipid nanoparticles (SLN) are a type of a carrier system that employs solid lipids as a matrix for drug delivery.1 The drug is molecularly dispersed within the lipid matrix, and the system is stabilized…
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FORMULATION DEVELOPMENT – A QbD Approach to Develop Extended Release Softgels
31. March 2015
Soft gelatin capsules (softgels) continue to be the oral solid dosage form preferred by consumers.1 Understandably, as they are easy to swallow and digest, effectively mask unpleasant tastes and smells, and have a pleasing appearance. Softgels also offer formulation and marketing…
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Docusate Sodium
12. March 2015 A Pharmaceutical Grade Excipient Docusate sodium is a pharmaceutical grade surfactant, making it an efficient emulsifier, wetting, dispersing and solubilizing agent. Cytec offers Docusate sodium as a 100%…
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A Self-microemulsifying Drug Delivery System (SMEDDS) for a Novel Medicative Compound Against…
08. February 2015
AJS is the code name of an untitled novel medicative compound synthesized by the Tasly Holding Group Company (Tianjin, China) based on the structure of cinnamamide, which is one of the Biopharmaceutics Classification System (BCS) class II drugs. The drug has…
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Excipients by function
In addition to the different origins and roles for the formulation of a drug product excipients can differentiated by their function. The major groups of excipients by function are:
Anti-Foaming Agents / Defoamer
Antioxidants
Binders
Coatings
Colorants / Colors…
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