Pharma Excipients
Emulsifier
Formulation Design and characterization of Antifungal Emulgel for Topical Delivery
Emulgel is the latest generation in novel drug transport device used for manage launch of emulsion and gel for the reason of topical use. The steadiness of emulsion is increased, while it is integrated into gel. Miconazole is an antifungal drug has been used inside the remedy of dermatophytic…
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Optimization of ultra-sonicated homogenization conditions of fish oil emulsions to improve…
This study aimed to improve the quality characteristics of fish oil microcapsules from monolayer and multilayer emulsions by optimizing the ultra-sonicated homogenization conditions to obtain a stable source of omega-3 fatty acids to add in food matrix. For that, a response surface methodology trial…
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Evaluation of tricalcium citrate as a direct compressible diluent using the SeDeM Expert Diagram…
ABSTRACT
Oral administration of medicine is one of the most common delivery routes still in use today. Various dosage forms are administered via the oral route including tablets, capsules, syrups, solutions and emulsions. Tablets constitute a large part of orally available dosage forms due to ease…
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Enhanced stability and skin permeation of ibuprofen-loaded solid lipid nanoparticles based binary…
Hypothesis
The type of emulsifier selected has an impact on the physicochemical properties of solid lipid nanoparticles (SLNs). This study was designed to compare the effects of emulsifiers on the physicochemical properties and in vitro skin performance of SLNs prepared from a binary mixture of…
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Formulating with Self-Emulsifying Cream Bases: Kolliphor® CSL
Kolliphor® CSL (cetostearyl alcohol, sodium lauryl sulfate, and sodium cetostearyl sulfate) by BASF is an emulsifier and structuring agent combination product that is suitable for O/W (oil-in-water) formulations.
Its strategically designed self-emulsifying properties allow it to be used in…
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Highly Concentrated Emulsions Containing High Loads of Pterostilbene
Abstract
Pterostilbene is a highly researched molecule due to its bioactivity. However, its hydrophobicity limits its application. For this reason, researchers have sought to encapsulate pterostilbene (namely, in oil-in-water emulsion) to increase its availability. Studies are lacking when it comes…
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The impact of common pharmaceutical excipients on the gut microbiota
ABSTRACT
Introduction
Increasing attention is being afforded to understanding the bidirectional relationships that exist between oral medications and the gut microbiota, in an attempt to optimize pharmacokinetic performance and mitigate unwanted side effects. While a wealth of research has…
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Nose to brain delivery of radiolabeled chemotherapeutic micelles: Meeting the unmet needs of brain…
The blood brain barrier postures colossal challenges to the CNS delivery of drugs administered via the oral/parenteral route. In conditions like glioblastoma where mean patient survival rate is mere 15months from diagnosis, outwitting the blood brain barrier pathway could be a boon to the patient…
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Rational Design of Topical Semi-Solid Dosage Forms – How Far Are We?
Specific aspects of semi-solid dosage forms for topical application include the nature of the barrier to be overcome, aspects of susceptibility to physical and chemical instability, and a greater influence of sensory perception. Advances in understanding the driving forces of skin penetration as…
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Transdermal Delivery of Estradiol Simultaneously Possessing Rapid Release and Sustaine Release…
Dissolving microneedle (DMN) has been researched as a drug delivery technology that improves drug molecule transportation through the skin with little discomfort. However, the sluggish drug absorption, poor skin dissolution, and lengthy time lags of DMN have limited its potential uses. The aim of…
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