Pharma Excipients
Emulsifier
Fabrication of Sustained Release Curcumin-Loaded Solid Lipid Nanoparticles (Cur-SLNs) as a Potential…
The goal of current research was to develop a new form of effective drug, curcumin-loaded solid lipid nanoparticles (Cur-SLNs) and test its efficacy in the treatment of lung cancer. Different batches of SLNs were prepared by the emulsification–ultrasonication method. For the optimization of…
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Nanotechnology based drug delivery systems for the treatment of anterior segment eye diseases
Diseases affecting the anterior segment of the eye are the primary causes of vision impairment and blindness globally. Drug administration through the topical ocular route is widely accepted because of its user/patient friendliness - ease of administration and convenience. However, it remains a…
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Investigation of In Vivo Bioavailability Enhancement of Iloperidone-Loaded Solid…
Purpose
The current research focuses on enhancement of in vitro dissolution and in vivo bioavailability characteristics of iloperidone (IP) by formulation, optimization of L-SNEDDS using Box-Behnken design (BBD), and desirability function. L-SNEDDS were transformed into free-flowing powders by…
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A new oral self-emulsifying drug delivery system improves the antileishmania efficacy of…
The aim of this study was to develop, characterize and evaluate the in vivo oral efficacy of self-emulsifying drug delivery systems (SEDDS) containing fexinidazole (FEX) in the experimental treatment of visceral leishmaniasis (VL). The developed FEX-SEDDS formulation presented as a clear, yellowish…
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PHOSAL® H 50: Liquid Phospholipids Derived from Sunflower
The Natural All-Rounder
Lipoid’s PHOSAL® H 50 is a liquid formulation of purified phosphatidylcholine (PC) and oil from 100 % sunflower. This unique, pure and natural liquid formulation can serve as a solubilizer for lipophilic actives and can help to disperse lipid phases into aqueous systems by…
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Nanoemulgel: A Novel Nano Carrier as a Tool for Topical Drug Delivery
Abstract
Nano-emulgel is an emerging drug delivery system intended to enhance the therapeutic profile of lipophilic drugs. Lipophilic formulations have a variety of limitations, which includes poor solubility, unpredictable absorption, and low oral bioavailability. Nano-emulgel, an amalgamated…
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Incorporating a Lipophilic Disulfide-Bridged Linoleic Prodrug into a Self-Microemulsifying Drug…
The oral absorption of paclitaxel (PTX) is restricted by poor solubility in the gastrointestinal tract (GIT), low permeability, and high first-pass metabolism. Lipid carriers, such as a self-microemulsifying drug delivery system (SMEDDS), have been deemed as promising vehicles for promoting oral…
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Plant Bioactive Ingredients in Delivery Systems and Nanocarriers for the Treatment of Leishmaniasis:…
Background: This study was designed considering the challenges of leishmaniasis treatment and the benefits of carriers of drug delivery systems to review plant bioactive ingredients in delivery systems and nanocarriers for the treatment of leishmaniasis.
Methods: The methodology of this review…
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Solid Lipid Microparticles by Spray Congealing of Water/Oil Emulsion: An Effective/Versatile Loading…
Spray congealing technique was exploited to produce solid lipid microparticles (SLMp) loaded with a highly water-soluble drug (metoclopramide hydrochloride) dissolved in the aqueous phase of a water in oil (W/O) emulsion. The use of an emulsion as starting material for a spray congealing treatment…
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Modeling digestion, absorption, and ketogenesis after administration of tricaprilin formulations to…
At present, tricaprilin is used as a ketogenic source for the management of mild to moderate Alzheimer’s disease. After administration of the medium-chain triglyceride, tricaprilin is hydrolyzed to octanoic acid and further metabolized to ketones, acting as an alternative energy substrate for the…
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