Filler excipients are used to increase the volume of the material to enable easier processing of the ingredients and make it into a size suitable for consumption. Moreover, they can stabilize the product and help during manufacturing.
Pharma Excipients
Filler
The Inhalac family by Meggle – See the brochure
MEGGLE’s sieved, milled and micronized alpha-lactose monyhydrate for dry powder inhalation: InhaLac®
General information
The delivery of active pharmaceutical ingredients (APIs) via the lung is becoming increasingly important as ever more patients all over the world suffer from chronic respiratory…
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The Use of Sodium Alginate in Extended Release Tablet Formulations
Extended release tablets are commonly based on partially synthetic cellulose ethers, such as hypromellose (HPMC), hydroxyethyl cellulose (HEC), or hydroxypropyl cellulose (HPC). Alginates offer an interesting, all-natural alternative to these polymers. The aim of the present study was to…
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Impact of alternative lubricants on process and tablet quality for direct compression
Internal lubrication with magnesium stearate (MgSt) is associated with a reduced tensile strength and prolonged disintegration and dissolution times. In the current study, alternative lubricants to MgSt were compared with regard to lubrication efficacy and their impact on tablet properties. The…
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Biochar as a processing additive in poly (butylene adipate-co-terephthalate) (PBAT)
Poly (butylene adipate-co-terephthalate) (PBAT) is a promising alternative to non-biodegradable plastics in agricultural applications. However, it is usually blended with other materials to find a balance of strength, cost, and iodegradability. There is a need to understand the role of additives and…
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Compounding Tailored Veterinary Chewable Tablets Close to the Point-of-Care by Means of 3D Printing
Certain patient populations receive insufficient medicinal treatment due to a lack of commercially available products. The number of approved veterinary products is limited, making animals a patient population with suboptimal medicinal treatments available. To answer to this unmet need, compounding…
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The Performance of PROSOLV® EASYtab SP in Four Medium-Dose, Direct Compression Formulations with…
In the present study, the performance of PROSOLV® EASYt ab SP was tested in four DC formulations with different model APIs. Each of the selected APIs presented a particular challenge in terms of producing tablets with suitable hardness, weight uniformity, content uniformity and/or reliable…
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Lactose – a muti-talent Excipient
Meggle took a closer look at the multi-functional excipient lactose. Have a look at the background information for lactose as a pharmaceutical excipient:
Multi-talent milk – Components at a glance
Besides fat, minerals, proteins, and water, a very specific sugar is one of the main components of…
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Semi-solid extrusion 3D printing of tailored ChewTs for veterinary use – A focus on…
Currently, there are a few or none marketed gabapentin veterinary products, leading to treatment with compounded dosage forms or off-label use of human-marketed products. With the said approaches, there are significant risks of preparation errors, rendering these practices suboptimal. A new…
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A Multivariate Methodology for Material Sparing Characterization and Blend Design in Drug Product…
This study developed a material and time saving method for powder characterization. Building on an earlier developed raw material property database for use towards development of pharmaceutical dry powder processes, blends were selected in an efficient way to include maximal variability of the…
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Design of xerogel pill with good swallowing performance through wet milling and drop freeze-drying…
A novel dosage form with dose-adjusting and swallow-assisting functions, named “xerogel pills,” was developed for pediatric or geriatric patients. It is a multiple-unit dosage form in which a single dose is divided into several pills. The pills are double-structured small spheres with an inner drug…
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