Pharma Excipients
Film former
Developing methodology to evaluate the oral sensory features of pharmaceutical tablet coatings
Acceptability of medicines is critical for effective pharmacotherapy. The aim of this study was to investigate the oral sensory properties of tablet coatings to determine how mouthfeel can improve acceptability. A randomised double-blind study was performed in 84 adult volunteers (51% ≥55 years).…
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Providing Clean Label Solutions for Vitamins & Supplements
In the global dietary supplement market, consumer demands for cleaner labels continues to drive the development of new and innovative products. Additionally, regulatory agencies are also increasingly active in ensuring the safety of food additives used in our daily lives.
As ingredients such as…
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Development of a dosing device for individualized dosing of orodispersible warfarin films
Individualized medicine is relevant to ensure safe and efficient pharmacotherapy. It requires a suitable dosage form and a matching dosing device to enable flexible dosing serving the needs of individual dose requirements. For oral films no flexible dosing option is available until today. This study…
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How to assess oral dispersible film quality?
In recent years, there has been a tendency toward creating innovative, easy to use and patient-friendly drug delivery systems suitable for every consumer profile, which would ensure safety, stability and acceptability of a drug. One of the relatively novel and promising approaches is the manufacture…
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Polymer Distribution and Mechanism Conversion in Multiple Media of Phase-Separated…
Phase-separated films of water-insoluble ethyl cellulose (EC) and water-soluble hydroxypropyl cellulose (HPC) can be utilized to tailor drug release from coated pellets. In the present study, the effects of HPC levels and the pH, type, ionic strength and osmolarity of the media on the release…
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Characterisation and optimisation of diclofenac sodium orodispersible thin film formulation
Oral Thin Film (OTF) is a newly emerging drug delivery system which has many benefits for patients. Although there has been some formulation of OTF products, these have mainly been as confectionary or dental health products. The most significant benefit of this dosage format will only be realised…
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Optimization of Coating Processes of Mini Tablets with Polyvinylpyrrolidone Solutions in an Acoustic…
The aim of the current study is to optimize the bed fluidized coating process of mini tablets by means of an acoustic levitator. The optimized coating parameters, which have to be set in a fluidized bed reactor, can be determined by means of contactless levitation of a single mini tablet in an…
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A Study on the Applicability of Multiple Process Analysers in the Production of Coated Pellets
Process analytical technology (PAT) has become an important factor in design, analysis and control of complex technological processes. In the present study, pellet coating process was monitored using four different PAT approaches, i.e. near-infrared (NIR) spectroscopy, Raman spectroscopy, in-line…
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Gliding performance of solid oral dosage form film coatings using an artificial mucous layer
Oral drug delivery technology is mainly provided in the form of solid oral dosage forms (SODF) that have to be swallowed intact and move throughout the oro-esophageal system to release the drug content in the stomach or intestine. As there is growing evidence for an increasing prevalence of impaired…
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Titanium dioxide free coatings – Biogrund information
For decades, titanium dioxide (TiO2) has been used as a white pigment due to its very high opacity and brightness. Therefore, it has a wide range of applications, from being a colouring ingredient of pharmaceutical film coating, to food application colouring.
On the basis of current…
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