Pharma Excipients
Film former
A new melatonin oral delivery platform based on orodispersible films
An innovative delivery system for melatonin, based on the incorporation of solid lipid microparticles in orodispersible films (ODFs) made of maltodextrin, was designed and developed. Lipid microparticles at two different melatonin concentrations (10 and 20% w/w) were produced by the spray congealing…
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Current Developments in Excipient Science – Implication of Quantitative Selection of Each…
Implication of Quantitative Selection of Each Excipient in Product Development
Excipients’ role in designing different dosage forms does not require any introduction. These are the additives that are added to the formulation along with pharmacologically active substance. The main purpose of adding…
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In vitro drug release from acetylated high amylose starch-zein films for oral colon-specific drug…
This study describes the preparation of free films of zein with and without acetylated high amylose maize starch (HAS) and their corresponding coated tablets as a novel approach to colonic drug delivery. We hypothesise that the embedding of a digestible starch component within the inert zein would…
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What are pharmaceutical film coatings? Part 1 -Tablets
There a many reasons for coating of different pharmaceutical products such as pellets, granules, capsules, powders and crystals. In this article, we will concentrate on the film-coating of tablets.
The procedure of coating tablets is a complex process that results in the forming of a thin layer…
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Sustainable Application of Biopolymer
The widespread use of materials produced from petrochemical substrates, such as plastics, can exert an adverse impact on the environment, especially on creatures living therein, including fish and turtles in the sea, as well as the birds inhabiting the vicinity that may die from mistaking plastics…
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Understanding the release performance of pellets with hydrophobic inclusions in sustained-release…
The aim of this study was to evaluate how the addition of hydrophobic inclusions to sustained-release pellet film coat can affect drug release. Sustained-release formulations, in particular multiparticulate systems are gaining popularity because they are able to reduce the dosing frequency of drugs…
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Experimental and Modeling Study of Drug Release from HPMC-Based Erodible Oral Thin Films
In this work hydroxypropyl methylcellulose (HPMC) fast-dissolving thin films for oral administration are investigated. Furosemide (Class IV of the Biopharmaceutical Classification System) has been used as a model drug for in vitro release tests using three different set-ups: the Franz cell, the…
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An introduction to pharmaceutical film coatings
A wide variety of pharmaceutical products, including pellets, granules, capsules, powders, and crystals are often film coated. In this present article, we will concentrate on the film-coating of tablets.
The procedure of coating tablets is a complex process that results in the forming of a thin…
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Development of high drug loaded pellets by Design of Experiment and population balance model…
Medicines of drug coated inert pellets filled into hard capsules or compressed into tablets are already on the market, until now, their number is limited and there are few systematic investigations of possible coating amounts. Pellets of microcrystalline cellulose were coated with a model drug…
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Designing pH-Responsive Biodegradable Polymer Coatings for Controlled Drug Release via Vapor-Based…
We present the design of a novel pH-responsive drug release system that is achieved by solventless encapsulation of drugs within a microporous membrane using a thin capping layer of biodegradable polymethacrylic anhydride (PMAH) coating. The coating was synthesized via a mild vapor polymerization…
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