Pharma Excipients
Film former
Enteric-coating film effect on the delayed drug release of pantoprazole gastro-resistant generic…
Abstract
Background: Enteric coating films in acidic labile tablets protect the drug molecule from the acidic environment of the stomach. However, variations in the excipients used in the coating formulation may affect their ability to provide adequate protection. This study is the first to…
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Comparison of Hydroxypropyl Methylcellulose and Alginate Gel Films with Meloxicam as Fast…
Abstract
The aim of the study was the preparation and comparison of two types of orodispersible gel films (ODF) by the solvent casting method. Natural polymers: sodium alginate (ALG) or hydroxypropyl methylcellulose (HPMC) were used as the gel film formers, and Kollidon or microcrystalline…
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In Vitro and In Vivo Evaluation of Composite Oral Fast Disintegrating Film: An Innovative Strategy…
Here, we evaluate the feasibility of co-loading plain ranitidine hydrochloride (RHCl) and microencapsulated flurbiprofen (FBP) in a Lycoat® RS780-based oral fast disintegrating film (ODF). These films were developed by the solvent casting method to minimize the adverse effects of FBP and reduce the…
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Integrated in vitro – In vivo – In silico studies in the pharmaceutical development of propranolol…
In order to exploit the advantage of drug delivery through the buccal mucosa, mucoadhesive buccal films with propranolol hydrochloride based on polyethylene oxide, hydroxypropyl methylcellulose, and polyvinyl alcohol have been developed. The aim of this study was the development,…
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Role of additives in starch-based edible films and coating: A review with current knowledge
Edible films and coating provide a potentially effective method for preserving fresh food products by reducing moisture loss, regulating respiration rate, improving surface smoothness, and or preventing microbial growth during their storage. Concurrently, starch has proven for its inexpensive,…
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Formulation and Characterization of Buccal Films Containing Valsartan with Additional Support from…
The present study was aimed to the development and characterization of valsartan-containing buccal films with an introduction to a novel technique of image analysis. Visual inspection of the film provided a wealth of information that was difficult to quantify objectively. The obtained images of the…
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Anionic and Ampholytic High-Amylose Starch Derivatives as Excipients for Pharmaceutical and…
Many chemical modifications of starch are realized in organic (mostly methanol) phase, allowing high degrees of substitution (DS). Some of these materials are used as disintegrants. To expand the usage of starch derivative biopolymers as drug delivery system, various starch derivatives obtained in…
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Pharmaceutical characterization and dissolution behavior of ibuprofen/Soluplus solvent cast films
Purpose: To characterize the physicochemical and dissolution properties of Soluplus®/ibupofen solid
dispersions prepared by solvent casting technique.
Methods: Soluplus® was used as a film-forming agent whereas ibuprofen served as a poorly soluble biopharmaceutics classification system (BCS)…
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Development of 3D Printed Multi-Layered Orodispersible Films with Porous Structure Applicable as a…
The direct tailoring of the size, composition, or number of layers belongs to the advantages of 3D printing employment in producing orodispersible films (ODFs) compared to the frequently utilized solvent casting method. This study aimed to produce porous ODFs as a substrate for medicated ink…
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Amphotericin B- and Levofloxacin-Loaded Chitosan Films for Potential Use in Antimicrobial Wound…
Levofloxacin (LVX) and amphotericin B (AMB) have been widely used to treat bacterial and fungal infections in the clinic. Herein, we report, for the first time, chitosan films loaded with AMB and LVX as wound dressings to combat antimicrobial infections. Additionally, we developed and validated a…
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