Pharma Excipients
Film former
High-amylose maize starch as a novel film former to develop oral films with excellent mechanical…
Aim: The study involved the development and optimization of the fast-dissolving oral films of salbutamol sulfate using high-amylose maize starch (HAMS) as a novel film former by comparison with the HPMC E50 (hydroxy propyl methyl cellulose) films. The high aqueous solubility, low dose, and low…
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Modernising Orodispersible Film Characterisation to Improve Palatability and Acceptability Using a…
Orodispersible films (ODFs) have been widely used in paediatric, geriatric and dysphagic patients due to ease of administration and precise and flexible dose adjustments. ODF fabrication has seen significant advancements with the move towards more technologically advanced production methods. The…
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Pharmaceutical, Biomedical and Ophthalmic Applications of Biodegradable Polymers (BDPs): Literature…
In the last few decades, the interest in biodegradable materials for biomedical applications has increased significantly. Both natural and synthetic biodegradable polymers (BDPs) have been broadly explored for various biomedical applications. These include sutures and wound dressings, screws for…
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Concept of Orodispersible or Mucoadhesive “Tandem Films” and Their Pharmaceutical Realization
Orodispersible or mucoadhesive films as a patient-oriented dosage form for low-dosed drugs are usually produced using solvent casting. This paper presents a modification of the solvent casting technique that aimed to divide oral films into two or more compartments.
The proposed objectives and…
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Management and control of intraocular pressure applying macitentan hydrogel film formulation:…
Background
Macitentan blocks endothelin receptors in order to control the pulmonary arterial hypertension (PAH). Oral administration of macitentan is associated with painful urination and troubled breathing.
Objectives
Formulated macitentan hydrogel film was used for examining the control of…
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Design and physico-mechanical evaluation of fast-dissolving valsartan polymeric drug delivery system…
Objective(s): Chronic hypertension is a pervasive morbidity and the leading risk factor for cardiovascular diseases. Valsartan, as an antihypertensive drug, has low solubility and bioavailability. The application of orodispersible films of valsartan is suggested to improve its bioavailability. With…
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Optimized hydration dynamics in mucoadhesive xanthan-based trilayer vaginal films for the controlled…
Karaya gum, pectin and xanthan gum have been tested as candidates for manufacturing mucoadhesive trilayer films containing ethylcellulose and chitosan for the vaginal administration of the antiviral Tenofovir (TFV). The swelling profile correlated with the amount of mobile dipoles determined by …
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3D-Printed Products for Topical Skin Applications: From Personalized Dressings to Drug Delivery
3D printing has been widely used for the personalization of therapies and on-demand production of complex pharmaceutical forms. Recently, 3D printing has been explored as a tool for the development of topical dosage forms and wound dressings. Thus, this review aims to present advances related to the…
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QbD steered fabrication of Pullulan-Terminalia catappa-Carbopol®971P film forming gel for improved…
In present work, a film forming gel (FFG) was developed through ingenious amalgamation of polymers: Pullulan, Terminalia catappa and Carbopol®971P ® for cutaneous delivery of clotrimazole (CTZ) employing D-optimal mixture design. The developed FFG possess pseudoplastic, viscoelastic, thixotropic…
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Development of buccal film formulations and their mucoadhesive performance in biomimetic models
When developing buccal films for oromucosal drug administration, adhesion is essential to ensure sufficient time for permeation of the active ingredient(s) through the oral mucosa and avoid the detachment and subsequent swallowing of the film. In this study, biomimetic materials were evaluated as a…
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