Pharma Excipients
Film former
Orodispersible Film Loaded with Enterococcus faecium CRL183 Presents Anti-Candida albicans Biofilm…
Background: Probiotic bacteria have been emerging as a trustworthy choice for the prevention and treatment of Candida spp. infections. This study aimed to develop and characterize an orodispersible film (ODF) for delivering the potentially probiotic Enterococcus faecium CRL 183 into the oral cavity,…
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Development and evaluation of a composite dosage form containing desmopressin acetate for buccal…
Desmopressin acetate (DDAVP) is an oligopeptide indicated for the treatment of primary nocturnal enuresis, for example. The poor oral bioavailability of DDAVP accelerated a shift to alternative routes of administration like nasal and oromucosal, whereby nasal administration results in high…
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Development of Mucoadhesive Buccal Film for Rizatriptan: In Vitro and In Vivo Evaluation
The reduced therapeutic efficacy of rizatriptan in migraine treatment is primarily due to low oral bioavailability and extensive first pass metabolism. The purpose of this investigation was to optimize the thin mucoadhesive buccal film of rizatriptan and assess the practicability of its development…
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Fabrication and Characterization of Poly (vinyl alcohol) and Chitosan Oligosaccharide-Based Blend…
In the present study, we report the development of poly (vinyl alcohol) (PVA) and chitosan oligosaccharide (COS)-based novel blend films. The concentration of COS was varied between 2.5–10.0 wt% within the films. The inclusion of COS added a brown hue to the films.
FTIR spectroscopy revealed that…
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Development, optimization and in-vivo evaluation of cyanocobalamin loaded orodispersible films using…
Vitamin B12 deficiency is associated with high risks of cognitive decline, neuropathy, megaloblastic anaemia and depression. Therefore, there is a need to develop an innovative formulation of vitamin B12 to restore optimal serum vitamin B12 levels (200 to 900 pg/mL), particularly in dysphagia…
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Insulin fast-dissolving film for intranasal delivery via olfactory region, a promising approach for…
The present work aimed to formulate intranasal insulin fast-dissolving films for treatment of anosmia in patients post COVID-19 infection. Variant films were prepared employing the casting method and using hydroxypropyl methyl cellulose and polyvinyl alcohol. The formulated films were investigated…
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Bioadhesive Films as Drug Delivery Systems
Bioadhesive films are considered a novel drug delivery system that provides improved therapy and better patient compliance than conventional dosage forms. The type and concentration of polymer or the blend of polymers used are important factors that can influence the properties of bioadhesive films,…
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Effect of Eudragit® NE 40D on The Properties of Pectin Film-Based Polymer Blends
In this work, pectin was used as the primary polymer component while Eudragit® NE 40D was used as polymer blending for the preparation of the thin films. Glycerin was used as a plasticizer. The samples were prepared by a solvent casting method, and their thickness, physicomechanical properties, and…
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Quaternary polymethacrylate−magnesium aluminum silicate film formers: Stability studies for tablet…
The objective of this work was to investigate the long-term stability of quaternary polymethacrylate-magnesium aluminum silicate (QPM-MAS) nanocomposite film-coated tablets compared to that of QPM-coated tablets. QPM- and QPM-MAS-coated tablets prepared without or with a curing process at 60 °C for…
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Development of Biodegradable Films Loaded with Phages with Antilisterial Properties
The inhibitory and bactericidal capacity of Listex P100 bacteriophage has been studied against different concentrations of Listeria monocytogenes in stationary and exponential phases. Three different matrices were employed to developed films incorporating Listex P100: (1) sodium caseinate, (2)…
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