Pharma Excipients
Film former
Formulation development of SYN-004 (ribaxamase) oral solid dosage form, a β-lactamase to prevent…
SYN-004 (ribaxamase) delayed release drug product is a multi-particulate, hard capsule for oral delivery of a recombinant β-lactamase enzyme designed to degrade β-lactam antibiotics administered intravenously, and thus prevent colon dysbiosis. Here we describe the development of the SYN-004 enteric…
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Niclosamide Inhalation Powder Made by Thin-Film Freezing: Pharmacokinetic and Toxicology Studies in…
In this work, we have developed and tested in vivo a dry powder form of niclosamide made by thin-film freezing (TFF) and administered it by inhalation to rats and hamsters. The niclosamide dry powder, suitable for inhalation, is being developed as a therapeutic agent against COVID-19 infection.…
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Influence of Plasticizers on the pH-Dependent Drug Release and Cellular Interactions of…
Vaginal films featuring the pH-dependent release of tenofovir (TFV) were developed for the prevention of sexual transmission of human immunodeficiency syndrome (HIV). Films based on hydroxypropyl methylcellulose and zein were prepared incorporating different plasticizers and evaluated for in vitro …
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Comparative Evaluation of Pellet Cushioning Agents by Various Imaging Techniques and Dissolution…
Most of the commercially available pharmaceutical products for oral administration route are marketed in the tablet dosage forms. However, compression of multiparticulate systems is a challenge for the pharmaceutical research and industry, especially if the individual unit is a coated particle, as…
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Investigating the influence of various plasticiser on the properties of Kollicoat® SR 30 D based…
INTRODUCTION
Plasticiser play a decisive role in the application of functional films, especially, if an aqueous dispersion containing a water insoluble polymer is used. For the water insoluble sustained release film forming polymer PVAc, both elongation at break and minimum film forming temperature…
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Permeation and Absorption of Ethanol/Water Mixture through Ethylcellulose Film
Ethylcellulose (EC) is water-insoluble, rate-controlling polymer which has been widely used as coatings of oral solid dosage forms, excipients for amorphous solid dispersions of active pharmaceutical ingredients (APIs), and films for buccal and transdermal drug delivery systems. The interaction of…
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Development and Characterization of Pullulan-based Orally Disintegrating Films Containing Amlodipine…
The aim of this study was to prepare pullulan-based orally disintegrating films (ODFs) containing amlodipine besylate, an anti-hypertensive drug, by the solvent casting method. For this purpose, nine different ODF formulations (F1-F9) were prepared by using different plasticizers (glycerol,…
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Influence of Polyvinyl Alcohol (PVA) on PVA-Poly-N-hydroxyethyl-aspartamide (PVA-PHEA)…
This study was conducted to formulate buccal films consisting of polyvinyl alcohol (PVA) and poly-N-hydroxyethyl-aspartamide (PHEA), to improve the dissolution of the drug through the oral mucosa. Ibuprofen sodium salt was used as a model drug, and the buccal film was expected to enhance its…
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Mechanical Characteristics of Orally Disintegrating Films: Comparison of Folding Endurance and…
The tensile test is the most widely used method for testing the mechanical characteristics of orally disintegrating films (ODFs). The other available test is the folding endurance (FE) test, which is more suitable for clarifying the actual strength during the manufacturing and dosing. However, the…
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Cellulose and its derivatives for application in 3D printing of pharmaceuticals
Background
Three-dimensional printing (3DP) has emerged as an advanced manufacturing technology capable of producing complex yet precise medicines intended for patient-centric drug therapy. However, printable materials currently available for 3DP are far too limited.
Area covered
The current…
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