Pharma Excipients
Film former
Enhanced Loading Efficiency and Mucoadhesion Properties of Gellan Gum Thin Films by Complexation…
Polymeric oral thin films (OTFs) were prepared by the casting method, combining gellan gum (GG), a water-soluble polysaccharide, and glycerol (Gly) as a plasticizing agent. GG-Gly films were investigated as potential systems for buccal drug delivery using fluconazole (Class I of the…
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Film forming systems for topical and transdermal drug delivery
Methyl ester derivatives of alginic acid have been evaluated as potential multifunctional excipients for pharmaceutical direct compression. The use of alginic acid as an excipient in tablet formulation is limited because of certain drawbacks such as low tablet hardness and poor compressibility. The…
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Design, fabrication and characterisation of drug-loaded vaginal films: State-of-the-art
Highlights
• Film technology provides platforms adaptable to the desired drug release profile.
• Several natural and synthetic polymers have been considered to obtain vaginal films.
• Plasticisers and other excipients allow modifying the relevant properties of films.
• Solvent…
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Evaluating the suitability of a pH-dependent pore former in a sustained release film-coating…
Since the development of polymers for enteric coating in the late 1950’s, numerous investigations have illustrated the application of these functional excipients such as poly(methacrylic acid-co-ethyl acrylate). Also mixtures with other polymers like poly(vinyl acetate) have already been well…
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How to prepare a ready-to-use film coating suspension – a Video explanation
Here is BIOGRUNDs step-by-step guide how to prepare a suspension.
Equipment & Material
Equipment: propeller stirrer, beaker
Material: Water, AquaPolish
Here is a simple calculation for a suspension with for example 20 % solids content:
AquaPolish® : 20 (%) 200g
Water : 80 (%) 800g…
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Quantification of porogen effect on the drug release from single- and multi-layered ethylcellulose…
The aim of this work was to develop a mathematical model to estimate the drug release from a conventional single-compartment reservoir pellet and extend its applicability to multi-compartment reservoir pellets. Conventional pellets were prepared by layering the drug onto starter-core then applying…
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Optimization and characterization of novel sustained release supermicro-pellet based dry suspensions…
Traditional dosage forms of dexibuprofen extremely limit their clinical applications because of the bitter taste and the frequent drug administration caused by the relatively short half-life of the drug.
This study aims to design novel sustained release (SR) supermicro-pellet based dry…
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Novel use of insoluble particles as disintegration enhancers for orally disintegrating films
The most important issue in the design of orally disintegrating films (ODFs) is the control of the ODFs' disintegration properties.
A better understanding of the mechanisms of ingredients used to promote or disturb the disintegration time of ODFs would improve the development of ODF formulations.…
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Preparation and evaluation of orally disintegrating film containing donepezil for Alzheimer disease
The present study intended to prepare orally disintegrating film (ODF) containing donepezil (DP) for the treatment of mild to moderate alzheimer disease.
HPMC and HPC, glycerine were used as film forming agents, plasticizer, respectively. The ODFs were prepared by solvent casting method. The…
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Developing methodology to evaluate the oral sensory features of pharmaceutical tablet coatings
Acceptability of medicines is critical for effective pharmacotherapy.
The aim of this study was to investigate the oral sensory properties of tablet coatings to determine how mouthfeel can improve acceptability. A randomised double-blind study was performed in 84 adult volunteers (51% ≥55 years).…
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