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Gelling agent
Influence of Sonication on the Molecular Characteristics of Carbopol® and Its Rheological Behavior…
Abstract
The effect of sonication on the molecular characteristics of poliacrylic acid (Carbopol® Ultrez 10) and its rheological behavior in aqueous dispersions and microgels containing 0.25 wt. % of the polymer was analyzed in this work by rheometry, weight-average molecular weight (Mw)…
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Formulating pharmaceutical topical dosage forms with high level of solvents and minimal quantity of…
Poster presented by Gattefosse and RCPE at the 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical (PBP) Technology, 18 - 21 March 2024, Vienna, Austria:
INTRODUCTION
Some APIs are very challenging to formulate. This is the case for example when the drug has limited…
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Formulation development of nanostructured lipid carrier-based nanogels encapsulating tacrolimus for…
The goal of this study was to formulate tacrolimus nanogel based on nanostructured lipid carrier (NLC) in order to improve the efficacy, aesthetic, and patient compliance for the treatment of psoriasis. The microemulsion method was used to create phase diagrams and NLCs were prepared using points…
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High mobility group box 1 cytokine targeted topical delivery of resveratrol embedded nanoemulgel for…
Resveratrol is a polyphenolic compound showing anti-inflammatory activity by inhibition of high mobility group box 1 cytokine responsible for the activation of nuclear factor-κB pathway in atopic dermatitis. To evaluate the efficacy of resveratrol through topical route we have developed…
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Polymeric Nanohydrogel in Topical Drug Delivery System
Nanohydrogels (NH) are biodegradable polymers that have been extensively studied and utilized for various biomedical applications. Drugs in a topical medication are absorbed via the skin and carried to the intended location, where they are metabolized and eliminated from the body. With a focus on…
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Skin-friendly textures – by Gattefossé
Caring for patients
Patient preferences and needs as well as therapeutic indication should be considered at early stage of development of topical or transdermal formulations.
To increase adherence to skin treatments, it is important to consider patient’s needs, when designing the dosage…
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Optimization of Hydroxypropyl Methylcellulose (HPMC) and Carbopol 940 in Clindamycin HCl Ethosomal…
Clindamycin HCl has anti-acne properties because it can inhibit the growth of Propionibacterium acnes (P. acnes) bacteria. However, the bioavailability of clindamycin HCl is less than 13% of the given dose, so it needs to be developed in the form of ethosomes to increase its bioavailability. This…
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Quality by design driven systematic development of nanoemulgel of clobetasol-17-propionate for…
Abstract
Nanoemulgels require two step formulation, the first one being formulation of nanoemulsion followed by the incorporation of nanoemulsion within a gel matrix. The current investigation aimed to formulate a Clobetasol-17-propionate (CP-17) nanoemulgel using QbD approach as anti-psoriatic for…
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Novel Therapeutic Hybrid Systems Using Hydrogels and Nanotechnology: A Focus on Nanoemulgels for the…
Abstract
Topical and transdermal drug delivery are advantageous administration routes, especially when treating diseases and conditions with a skin etiology. Nevertheless, conventional dosage forms often lead to low therapeutic efficacy, safety issues, and patient noncompliance. To tackle these…
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Lasmiditan Nanoemulsion Based In Situ Gel Intranasal Dosage Form: Formulation, Characterization And…
This study aimed to formulate lasmiditan (LAS) as a nanoemulsion in situ gel (NEIG) by utilising nanotechnology in order to escape the problems associated with the poor oral bioavailability of the drug. A study regarding the LAS solubility in different oils, surfactants and co-surfactants, was…
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