Pharma Excipients
Glidant
Development and Characterization of Liquisolid Tablets Based on Mesoporous Clays or Silicas for…
The aim of this work was to evaluate the effectiveness of mesoporous clays or silicas to develop fast-dissolving glyburide tablets based on a liquisolid approach. Selected clay (Neusilin®US2) and silica (Aeroperl®300) allowed preparation of innovative drug liquisolid systems containing…
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Effect of common excipients on intestinal drug absorption in Wistar rats
The aim of the present paper is to study the effect of common excipients on the permeability of atenolol (as drug absorbed mainly by passive diffusion) and rhodamine (as P-Glycoprotein substrate). Apparent permeability was measured by in situ perfusion method in Wistar rats using the Closed loop…
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Solidification of SMEDDS by fluid bed granulation and manufacturing of fast drug release tablets
Solidification of self-microemulsifying drug delivery systems (SMEDDS) is a rising experimental field with important potential for pharmaceutical industry, however fluid-bed granulation with SMEDDS is yet an unexplored solidification technique. The aim of the study was to solidify carvedilol-loaded…
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Development and Evaluation of Mucoadhesive Buccal Dosage Forms of Lidocaine Hydrochloride
Intraoral lidocaine formulations are applied in children and adults for pain relief. The potential risks associated with orally administered lidocaine due to accidental ingestions were highlighted in a warning letter by the US Food and Drug Administration (FDA). This increases the urgency for a need…
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Solving a sticking related tablet problem by multivariate statistics and computational tomographic…
This work identifies the cause of sticking of granules in an industrial process of tableting. Retrospective multivariate statistical analysis of industrial scale batches' records (PLS, properties and manufacturing conditions of granules and tablets) identified the air flow rate in both granulation…
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Three-dimensional aspects of formulation excipients in drug discovery: A critical assessment on…
Formulation/pharmaceutical excipients play a major role in formulating drug candidates, with the objectives of ease of administration, targeted delivery and complete availability. Many excipients used in pharmaceutical formulations are orphanized in preclinical drug discovery. These orphan…
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Problems during tablets manufacturing
Learn more about capping, lamination, picking and sticking as well as mottling, weight and hardness variations in tableting. All brought to to by Dr. Karim Maarif - founder of KMCD
Download the presentation here: some_basic_information_about_punches_tabletting_cycle__1581894721.pdf
Dr. Karim…
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Benefits of Co-processed High-Functionality Excipients in a Continuous Direct Compression Process…
Continuous manufacturing offers significant advantages over conventional batch processing such as smaller equipment, less footprint and no need for upscaling experiments. With these benefits, come challenges as well. In a fully continuous process, the excipients must be added through individual…
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Investigation of powder flowability at low stresses: Influence of particle size and size…
At moderate stresses, shear cells are the preferred method of powder flow measurement. However, several industrial processes operate at low stresses, where the determination of unconfined yield strength by the shear cell technique may be inconsistent, or found not to correlate with observed…
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PVA in Sustained Release Matrix Tablets – Wet Granulated vs Direct Compression – Poster
Polymer-based long-acting matrix tablets are often used to ensure patient compli- ance and API efficacy of orally applied drugs. Increasingly, polyvinyl alcohols (PVAs) are used as hydrophilic, swellable and erodible matrices in such sustained release (SR) tablets, as they show a prolonged API…
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