Pharma Excipients
Glidant
A material-saving and robust approach for obtaining accurate out-of-die powder compressibility
Density is an important material property for evaluating, or developing a tablet formulation. In-die compressibility data can be obtained using a small amount of powder with the help of a compaction simulator. However, compacts undergo volume expansion upon ejection from die.
Therefore, accurate…
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A systematic evaluation of poloxamers as tablet lubricants
Lubricants are important for both preserving the tooling of high-speed tablet presses and attaining quality tablets. Magnesium stearate (MgSt) is most commonly used due to its superior lubrication efficiency; however, it can lead to negative effects on tabletability and dissolution.
In this…
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Effect of disintegrants on the properties of multiparticulate tablets comprising starch pellets and…
A design of experiments (DOE) approach (2-level full factorial design) was used to investigate the effect of several formulation and process variables on the properties of fast disintegrating tablets comprising starch-based pellets and excipient granules and to optimize and validate the design…
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Co-processed excipients for direct compression of tablets
Tablets are the most frequently employed dosage form. Their advantage lies in their availability, easy administration, good stability, and low price. The easiest technology to produce tablets is direct compression, even though the use of the method requires overcoming many obstacles, mainly related…
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Predictive Model-Based Process Start-Up in Pharmaceutical Continuous Granulation and Drying
Continuous manufacturing (CM) is a promising strategy to achieve various benefits in the context of quality, flexibility, safety and cost in pharmaceutical production.
One of the main technical challenges of CM is that the process needs to handle transient conditions such as the start-up phase…
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Powder flow and mixing in different tablet press feed frames
Tablets can be manufactured using a rotary tablet press, which consists of a feed frame followed by the compression and compaction of the powder and subsequent ejection of the tablets.
From Quality by Design (QbD) perspectives the feed frame plays a critical role and effects products critical…
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On-Demand Manufacturing of Direct Compressible Tablets: Can Formulation Be Simplified?
Oral direct compressible tablets are the most frequently used drug products. Manufacturing of tablets requires design and development of formulations, which need a number of excipients. The choice of excipients depends on the concentration, manufacturability, stability, and bioavailability of the…
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Influence of mesoporous silica on powder flow and electrostatic properties on short and long term
Flow aid additives are commonly used in industries to improve the processing of cohesive powders.
A wide variety of additives are available: magnesium or calcium stearate, fumed and mesoporous silica, talc, etc. The efficiency of the additive depends on the cohesive forces playing a role in the…
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Direct Compression of Lactase Tablets with PROSOLV® EASYtab Nutra
The aim of this study was the development of lactase tablets that can be produced by direct compression. In order to avoid stability problems of the enzyme lactose, caused by high temperature and moisture, direct compression is the most suitable tableting process.
The performance of pure lactase…
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Predicting the critical quality attributes of ibuprofen tablets via modelling of process parameters…
Roller compaction is a low cost granulation process which application is sometimes limited by the granular loss of compactability and reduced drug dissolution rate. Hence, the design of a robust manufacturing process is key in order to ensure quality of tablets.
In this study, for ibuprofen…
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