Glidant

Mini-tablets are a pharmaceutical dosage form with a diameter of typically ≤ 3 mm. This is a potential dosage form for pediatrics since the small size of mini-tablets can ease the swallowing of medicines. In recent years there has been an increasing demand for research and development concerning…
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Despite being the most essential nutrient, water is commonly forgotten in the fields of pharmacy and nutrition. Hydration status is determined by water balance (the difference between water input and output). Hypohydration or negative water balance is affected by numerous factors, either internal…
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There is a current trend in pharmaceutical manufacturing to shift from traditional batch manufacture to continuous manufacturing. The purpose of this study was to test the ability of an integrated continuous direct compression (CDC) line, in relation to batch processing, to achieve consistent tablet…
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Implication of Quantitative Selection of Each Excipient in Product Development Excipients’ role in designing different dosage forms does not require any introduction. These are the additives that are added to the formulation along with pharmacologically active substance. The main purpose of adding…
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HiCel™ is a versatile co-processed excipient with added-value to standard microcrystalline cellulose types. See this short video to get an overview of why you should consider HiCel™ in your formulation work: Click here for more information on Sigachi´s excipients!
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Continuous powder feeding is a critical step in continuous manufacturing of solid dosage forms, as this unit operation should ensure the mass flow consistency at the desired powder feed rate to guarantee the process throughput and final product consistency. In this study, twin-screw feeding of a…
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The objective of this study is to investigate the variability in physiochemical and spectral properties of commercially available vegetable grade Magnesium Stearate (MgSt) samples, and to assess the correlation between physiochemical properties and near-infrared (NIR) and Raman spectroscopic…
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Flowability is a key consideration during the formulation and process development of oral solid dosage forms as it can have a critical impact on product quality. With a limited number of examples available in the literature, there is a need to better understand and share the typical flow properties…
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The use of natural polymer as excipients in pharmaceutical sector is expanding day by day. Low cost, safety degradable are the main causes that make them differ from other sources. Natural sources have wide range of varieties and characteristics. So they can be used…
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Granulation, the process of particle enlargement by agglomeration technique, is one of the most significant unit operations in the production of pharmaceutical dosage forms, mostly tablets and capsules. Granulation process transforms fine powders into free-flowing, dust-free granules that are easy…
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