Pharma Excipients
Glidant
Patient focused design and development of an age-appropriate paediatric formulation
02. March 2018 Introduction: The selection and design of dosage form for the paediatric population is a real challenge. Part of that challenge is to deal with the diversity of the patient population (new born to adolescent) (CPMP,…
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A Novel Approach for Dry Powder Coating of Pellets with Ethylcellulose
19. February 2018 The objective of this study was to assess the efficacy and the capability of a novel ethylcellulose-based dry-coating system to obtain prolonged and stable release profiles of caffeine-loaded pellets. Lauric and…
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Porous silica to provide on-dose product identification and to improve patient compliance
19. October 2017 Silica is well known in the pharmaceutical industry as an excipient. While pure silica, SiO2, is common, there are silicates of calcium, magnesium, and aluminum that are widely used as…
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Design and Evaluation of Solubility Enhancement of Poorly Soluble Drugs using Liquid Solid Compacts
30. September 2016
ABSTRACT
Oral dosage form is the physical form of a dose of a chemical compound used as a drug or medication intended for administration or consumption by the oral route. The poor dissolution rate of water insoluble drugs is still a substantial problem…
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Glidant effect of hydrophobic and hydrophilic nanosilica on a cohesive powder: Comparison of…
15. August 2016 Abstract The methods used for flow characterization of a powder mass include the angle of repose (AOR), Carr index (CI), and powder flow tester (PFT). The use of nanosilica as a flow modifier (glidant) is very…
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The central role of excipients in drug formulation
Active substances are rarely administered alone. For example, levothyroxine, a synthetic form of the thyroid hormone, indicated in the treatment of hypothyroidism, is administered at a very low dosage, ranging from 15 μg to 200 μg. These very small amounts of powder mean that it is not possible…
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Excipients by function
In addition to the different origins and roles for the formulation of a drug product excipients can differentiated by their function. The major groups of excipients by function are:
Anti-Foaming Agents / Defoamer
Antioxidants
Binders
Coatings
Colorants / Colors…
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