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Granulation
Hybrid models to support development of fluid bed granulation processes
Abstract
The hybrid modeling strategy which is based on the integration of mechanistic and data-driven models is proposed and applied on fluidized bed granulation processes. The tight combination of empirical process knowledge by means of a mechanistic model and the multivariate data from PAT…
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Oral Solid Dose – Direct Comparison of Pharmacel® 101 and Pharmacel® 102
High-quality excipients
Oral Solid Dose
A comprehensive range of highly consistent excipients for OSD formulations, including a full range of lactose (milled monohydrate, sieved monohydrate, micronized, anhydrous, spray dried, and granulated), cellulosics and starches portfolio comprising of…
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Comprehensive Review of Modern Techniques of Granulation in Pharmaceutical Solid Dosage Forms
ABSTRACT
This comprehensive review explores modern granulation techniques in pharmaceutical dosage forms along with conventional methods, focusing on dry granulation and wet granulation. Dry granulation techniques, including slugging, roller compaction, and pneumatic dry granulation, are…
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Advantages of combining polymers and lipids in extrusion processes
This poster was presented at the 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical (PBP) Technology, 18 - 21 March 2024, Vienna, Austria:
INTRODUCTION
Hot melt extrusion (HME) has become increasingly popular in pharmaceutical manufacturing over the last
decade1. This…
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Evaluation of binders in twin-screw wet granulation – Optimization of tabletability
Abstract
The influence of hydroxypropyl cellulose type (HPC-SSL SFP, HPC-SSL), concentration (2 %, 3.5 %, 5 %) and filler (lactose, calcium hydrogen phosphate (DCP)/microcrystalline cellulose (MCC)) on twin-screw wet granulation and subsequent tableting was studied. The aim was to identify the…
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Methocel™ Cellulose Ethers – A product that can do it all
THE POSSIBILITIES ARE ENDLESS
Pharmaceutical companies are continuously looking for ways to innovate – through new technologies such as controlled release systems and oral films, or through faster and more efficient manufacturing processes. Did you know that just one product can help do all of…
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Prolongation of the gastric residence time of caffeine after administration in fed state: Comparison…
Abstract
The aim of the present study was to investigate the gastroretentive capacity of different formulation principles. This was indirectly determined by the absorption behavior of caffeine from the dosage forms. A slow and continuous appearance of caffeine in the saliva of healthy volunteers…
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Premix technologies for drug delivery: manufacturing, applications, and opportunities in regulatory…
Abstract
Active pharmaceutical ingredients (APIs) and excipients can be carefully combined in premix-based materials before being added to dosage forms, providing a flexible platform for the improvement of drug bioavailability, stability, and patient compliance. This is a promising and…
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Development of novel portable NIR spectroscopy process analytical technology (PAT) tool for…
The aim of this research was to develop a process analytical technology (PAT) tool for monitoring the transformation process of the active ingredient ibuprofen into the fast-dissolving salt ibuprofen sodium during the wet granulation process. Two near-infrared (NIR) spectrophotometers, namely…
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Kollidon® 90 Evo – A highly effective water soluble binder with low impurity profile
Join the evolution of the BASF PVP portfolio! Kollidon® 90 Evo combines outstanding purity and innovative packaging.
Kollidon® 90 Evo is a highly effective binder with exceptional purity
Very low impurity profile, e.g., 2-pyrrolidone, aldehydes and hydrazine
Broad range of applications…
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