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Granulation
Lactose Spray Dried Monohydrate by Kerry
Excipients for direct tabletting, granulation, capsules, sachet filling and inhalation
Product Description
Lactose Overview
Lactose is a disaccharide of glucose and galactose obtained from the whey fraction of bovine milk. Depending on the temperatures used to crystallize and dry the…
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Sequential fixed-fluidized bed foam granulation (SFFBFG) and drying: Multivariate model development…
Foam granulation (FG) is a non-conventional technique in which a binding solution is sprayed as aqueous foam. The main objectives of this work are, converting a lab-scale fluidized bed dryer into a fluidized bed foam granulator and dryer. Second, developing a partial least squares regression model…
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Development of Inline Near-Infrared Spectroscopy Method for Real-Time Monitoring of Blend Uniformity…
Blending is a critical intermediate unit operation for all solid oral formulations. For blend uniformity testing, API content in the blend must be quantified precisely. A detailed study was conducted to demonstrate the suitability of inline NIR (near-infrared) spectroscopy for blend uniformity…
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Evaluation of the Formulation Parameter-Dependent Redispersibility of API Nanoparticles from Fluid…
The production of nanosuspensions of poorly soluble active pharmaceutical ingredients (API) is a popular technique to counteract challenges regarding bioavailability of such active substances. A subsequent drying of the nanosuspensions is advantageous to improve the long-term stability and the…
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Lactose Crystalline Monohydrate Family by Kerry
Excipients for direct tabletting, granulation, capsules, sachet filling and inhalation
Product Description
Lactose Overview
Lactose is a disaccharide of glucose and galactose obtained from the whey fraction of bovine milk. Depending on the temperatures used to crystallize and dry the…
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Assess the impact of your granulation process parameters with the STYL’ONE EVO
Powder granulation is commonly used in the pharmaceutical industry to improve flowability and compactibility of powders. In this case our customer wanted to develop a new direct compression grade of excipient produced by granulation.
This paper presents the methodology of MEDELPHARM Science…
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A novel approach to minimize loss of compactibility in a dry granulation process using…
Dry granulation via roller compaction is increasingly being used as granulation method for the production of oral solid dosage forms. Advantages of roller compaction include a simplified process compared to wet granulation and the inherently continuous nature of the process. A common problem of dry…
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Application of different models to evaluate the key factors of fluidized bed layering granulation…
Different modeling approaches were used to understand the key factors affecting the outcomes of pulse sprayed FBLG. A large amount of metformin hydrochloride (~83%) was layered onto Cellets® seeds to obtain directly compressible granules. The effect of spray rate, mass flow rate, inlet air…
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Material characterization with an extended Dwell Time compression profile on STYL’ONE NANO
During the development of a new drug, active materials are often available in small quantities for cost or process reasons. However, scientists have to understand their deformation behavior to design the best formulation possible and find suitable process parameters for production.
Compaction…
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Process Monitoring and Control of Drug Fluidized Bed Granulation and Its New Application
Nowadays, fluidized bed granulation is a widely used technique in the pharmaceutical industry. Several factors, including process settings, powder qualities, and binder properties, impact its performance. The monitoring of the fluidized bed granulation process is a complex process. This paper…
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