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Granulation
Investigation on in-vitro Dissolution and Tableting Properties Enhancement of Etodolac using…
Objectives: The objective of present study was to improve dissolution rate with tableting properties of BCS class II drug Etodolac, by melt granulation and sublimation techniques.
Materials and Methods: The granules of etodolac were formulated using Gelucire 50/13. The surface adsorbent Aerosil…
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Tailoring Rational Manufacturing of Extemporaneous Compounding Oral Dosage Formulations with a Low…
Low amounts of minoxidil in oral dosage forms are commonly prescribed as anti-alopecic pharmacological treatments. Side effects are usually related to individual susceptibility. However, poor drug content and mass uniformity can lead to a potential risk of overdosing, and higher chances to…
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Method Development and Validation of a Near-infrared spectroscopic method for In-line API…
Near-infrared spectroscopy (NIRS) is an excellent process analytical technology (PAT) tool for active pharmaceutical ingredient (API) quantification during fluidized granulation. Therefore, a portable near-infrared spectrometer combined with a new innovative method of extended iterative optimization…
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Switching from batch to continuous granulation: A Case Study of metoprolol succinate ER tablets
Continuous manufacturing (CM) has been used to produce several immediate release drug products. No extended-release (ER) product manufactured employing CM technology has been approved yet. This study investigated the critical aspects of switching from the batch mode of high shear granulation to the…
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System model driven selection of robust tablet manufacturing processes based on drug loading and…
Mechanistic process modeling presents an opportunity to reduce experimental burden, enabling relationships between process parameters and product attributes to be mapped out using in-silico experiments. A system model of a pharmaceutical tablet manufacturing process comparing dry granulation with…
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Improving Process Understanding in Roll Compaction
Roll compaction/ dry granulation is gaining importance. Numerous papers have been published and many attempts to model the process are available in the meantime. Johanson published a model in 1965, which is the basis for many further modifications until today. The aim of the paper is to improve…
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Sampling and diversion strategy for twin-screw granulation lines using batch statistical process…
Continuous manufacturing is now considered as a well-established technique by pharmaceutical companies. However, the limited number of filed applications reflects the complexity to translate a science that has been described in many publications to an actual drug product. Process stability…
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Relationship between powder properties and uniformity of ribbon property using feeding guider…
Roller compaction is a continuous dry granulation process in which two counter-rotating rollers compress the powder. The feeding of powder to the compaction zone has a significant effect on product quality in the process. This work aims to improve ribbon property uniformity using new feeding guiders…
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In-Depth Understanding of Granule Compression Behavior under Variable Raw Material and Processing…
Tablet manufacturing involves the processing of raw materials through several unit operations. Thus, the mitigation of input-induced variability should also consider the downstream processability of intermediary products. The objective of the present work was to study the effect of variable raw…
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The Effect of Binder Types on the Breakage and Drying Behavior of Granules in a Semi-Continuous…
Current study investigated the effect of different binder types on the granule drying process and the granule breakage behavior in a semi-continuous fluid bed dryer integrated in the C25 ConsiGma-system. The studied binders (i.e. hydroxypropyl pea starch, hydroxypropyl methylcellulose E15,…
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