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Granulation
In-line particle size measurement based on image analysis in a fully continuous granule…
The present paper serves as a demonstration how an in-line PAT tool can be used for rapid and efficient process development in a fully continuous powder to granule line consisting of an interconnected twin-screw wet granulator, vibrational fluid bed dryer, and a regranulating mill. A new method was…
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Efficient Development of Sorafenib Tablets with Improved Oral Bioavailability Enabled by…
An amorphous solid dispersion (ASD) of sorafenib (SOR) in hydroxypropyl methylcellulose acetate succinate (HPMC-AS), prepared by coprecipitation, was used to develop an immediate release tablet with improved oral bioavailability. An ASD of 40% drug loading with HPMC-AS (M grade), which exhibited…
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Effects of the controlled temperature in the production of high-shear granulated protein-containing…
During wet granulation, the sample can be exposed to considerable mechanical effects, moisture content and elevated temperatures, and during high-shear granulation the impeller and chopper speeds can induce elevated temperatures and influence the parameters of the products.
Highlights…
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Dry Powder Mixing Is Feasible in Continuous Twin Screw Extruder: Towards Lean Extrusion Process for…
Using discrete element method (DEM) modeling and near-infrared (NIR) spectroscopy, the feasibility of powder mixing in the initial pre-melting zones of a twin screw extruder using two independent feeders was studied. Previous work in the pharmaceutical and food industry has focused on mixing when…
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How to Tame Recalcitrant Ingredients with Technological Processes
Among the currently trending functional ingredients, interest in natural sources such as turmeric and its polyphenol, curcumin, has been increasing for years. The spice is not only in demand in the culinary world, but has also found great promise in both consumer and scientific applications.1 …
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Correlating Granule Surface Structure Morphology and Process Conditions in Fluidized Bed Layering…
A workflow for developing a multidimensional, linear correlation between the process conditions during fluidized bed spray granulation and the surface morphology of the resulting granules is presented. Spray coating experiments with Cellets®500 particles and sodium benzoate solution were performed…
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Deformation potential and tensile strength of tablets of a dry granulated formulation
The increase in solid fraction (SF) of a packed granule bed with pressure applied during the in-die compression process results in an evolution of the tablet's matrix and mechanical strength. In this case study, the tensile strength (TS) of a dry granulated microcrystalline cellulose (MCC)/mannitol…
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Predicting the particle size distribution in twin screw granulation through acoustic emissions
A non-destructive process analytical technology for monitoring the complex particle size distributions inherent to twin screw granulation (TSG) was presented, based on acoustic emissions (AE). AE spectra were collected during the wet granulation of lactose monohydrate at different liquid to solid…
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Analysis of the Effects of Process Parameters on Start-Up Operation in Continuous Wet Granulation
Toward further implementation of continuous tablet manufacturing, one key issue is the time needed for start-up operation because it could lead to lower product yield and reduced economic performance. The behavior of the start-up operation is not well understood; moreover, the definition of the…
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Flowing properties of spray-dried powders before and after granulation
Abstract
We study the flowing properties, the density and the packing dynamics of spray-dried powders produced with different nozzels and different airflow rates. At the exception of one powder, the obtained grains are small and have a low flowability due to cohesiveness. Therefore, an…
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