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Granulation
Evaluating mechanical properties and tabletability of pharmaceutical powders with a novel…
Developing new pharmaceuticals is costly and time-consuming. New methods are always in demand for various stages of product development. Investing in the early phases of development can save a significant amount of resources in the long term.
Tablet is still the most commonly used pharmaceutical…
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Application of mini ODTs and coin shaped ODTs with high performance excipients for pediatric…
Pediatric formulations are strongly demanded from healthcare professionals and caregivers. Currently, solid dosage forms have been studied as pediatric preparations.
In this article, we report the development of orally disintegrating tablets (ODTs) which shape are suitable for pediatric…
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Two-dimensional moisture content and size measurement of pharmaceutical granules after fluid bed…
In pharmaceutical wet granulation, drying is a critical step in terms of energy and material consumption, whereas granule moisture content and size are important process outcomes that determine tabletting performance. The drying process is, however, very complex due to the multitude of interacting…
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Evaluation of Binders in Twin-Screw Wet Granulation
The binders povidone (Kollidon 30), copovidone (Kollidon VA64), hypromellose (Pharmacoat 606), and three types of hyprolose (HPC SSL‑SFP, HPC SSL, and HPC SL‑FP) were evaluated regarding their suitability in twin-screw wet granulation. Six mixtures of lactose and binder as well as lactose without…
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Improved Manufacturability and In Vivo Comparative Pharmacokinetics of Dapagliflozin Cocrystals in…
Dapagliflozin (DAP), which improves glycemic control in patients with type 2 diabetes mellitus, has poor physical properties against heat and moisture, thus hindering its manufacturing potential. The superior physicochemical properties of a recently developed cocrystal of DAP and citric acid (DAP…
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Comparative Evaluation of Pellet Cushioning Agents by Various Imaging Techniques and Dissolution…
Most of the commercially available pharmaceutical products for oral administration route are marketed in the tablet dosage forms. However, compression of multiparticulate systems is a challenge for the pharmaceutical research and industry, especially if the individual unit is a coated particle, as…
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A novel approach to determine the granule density of milled ribbons using multi-stage air…
Determination of the granule density as a critical quality attribute during roller compaction/dry granulation provides an important parameter for further successful processing of the compacted materials. In this study, a novel approach was developed to determine the granule density using the…
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A review of high shear wet granulation for better process understanding, control and product…
High shear wet granulation (HSWG) is considered a complicated and multivariate pharmaceutical process that is influenced by a large number of variables derived from equipment, formulations, and processes. A better understanding and effective control of the granulation process are required to achieve…
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Development of probiotic orodispersible tablets using mucoadhesive polymers for buccal mucoadhesion
Objective: Probiotic bacteria, such as different lactobacilli strains, have successfully been used to treat gingivitis and periodontitis or caries. By formulating probiotics as orodispersible tablet (ODT), the benefits of this dosage form could be utilised. Without any further measures, the…
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Twin-screw granulation and high-shear granulation: the influence of mannitol grade on granule and…
Granule structure has a key influence on tablet critical quality attributes. The ability to control this structure through excipient choice is an important part of formulation development. Mannitol is a popular diluent and the choice of input grade has been shown to impact granule properties.…
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