Browsing Category
Granulation
PHARMACOAT® – Easy to use film coating material that provides an excellent finish
Shin-Etsu Chemical supplies the various excipients for pharmaceutical industry and developed PHARMACOAT® in the 1960s during the early days of film coating and since then it has been the subject of a continuous development and quality improvement.
The PHARMACOAT® grades are low viscous…
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Elucidation of processing parameters for the reverse engineering of tablets
Abstract
Reverse engineering can assist in decoding the formula and manufacturing parameters employed in innovator formulations. Generic pharmaceutical industries use it to develop generic cheaper versions of innovator tablets. Herein, we report the systematic application of reverse engineering in…
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Development and application of control concepts for twin-screw wet granulation in the ConsiGma-25:…
Abstract
Traditional operation modes, such as running the production processes at constant process settings or within a narrow design space, do not fully exploit the advantages of continuous pharmaceutical manufacturing. Integrating Quality by Control (QbC) algorithms as a standard component of…
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Benefits of an Optimal Tabletability DC Mannitol on Compression Setting Parameters
This case study was presented at the 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 18 - 21 March 2024, Vienna, Austria:
INTRODUCTION
An increasing number of APIs present stability challenges and corresponding tablets require to be formulated with protective…
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Optimizing API Load and Minimizing Tablet Weight Leveraging an Innovative DC Mannitol
Presented at the 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical (PBP) Technology, 18 - 21 March 2024, Vienna, Austria:
INTRODUCTION
Tablets with stability issues often use mannitol, a stable, water-soluble excipient compatible with most drugs. Direct compression is a…
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Tabletability of Roll Compacted Binary Mixtures of Dicalciumphosphate with Silicified and…
JRS Pharma presented three posters at the 2024 PBP World Meeting in Vienna. This is the second poster:
Introduction
Roll compaction/dry granulation (RCDG) is nowadays not only applied for water or heat sensitive active pharmaceutical ingredients, but has become a standard technique in…
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Twin-Screw Melt Granulation with PEG 8000: effect of binder particle size and processing temperature…
Introduction
High-drug-loaded tablets and capsules are desirable and are manufactured using granulation as an additional step. Replacing batch wet granulation with twin-screw melt extruder as a continuous solventless process is gaining popularity. PEG 8000 being one of the most popular…
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Implementation of near-infrared spectroscopy and convolutional neural networks for predicting…
Monitoring the particle size distribution (PSD) is crucial for controlling product quality during fluidized bed granulation. This paper proposed a rapid analytical method that quantifies the D10, D50, and D90 values using a Convolutional Block Attention Module-Convolutional Neural Network (CBAM-CNN)…
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Studying the API Distribution of Controlled Release Formulations Produced via Continuous Twin-Screw…
Abstract
Hydroxypropyl methylcellulose (HPMC) is a preferred hydrophilic matrix former for controlled release formulations produced through continuous twin-screw wet granulation. However, a non-homogeneous API distribution over sieve fractions with underdosing in the fines fraction (<150 µm) was…
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Assessing Abuse-Deterrent formulations utilizing Ion-Exchange resin complexation processed via…
Opioid misuse is a public health crisis in the United States. In response, the FDA has approved drug products with abuse-deterrent features to reduce the risk of prescription opioid abuse. Abuse-deterrent formulations (ADFs) typically employ physical or chemical barriers or incorporate…
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