Granulation

Powders are often granulated to improve their flow properties, content uniformity and processability. Dry granulation is increasingly becoming a preferred granulation technique in the pharmaceutical industry because it makes manufacturing and processing of moisture and heat sensitive active…
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Solid fraction is a key intermediate product attribute which significantly affects the granule characteristics prepared in a roller compaction (RC) process. Implementing the quality by design (QbD) in pharmaceutical manufacturing requires quantitative insight into the impacts of process parameters…
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Moisture plays a major role in determining the attributes of granules prepared by fluidized bed granulation (FBG). Here, a semi-theoretical droplet-based evaporation rate model was developed and incorporated into moisture mass-enthalpy balances to simulate the temporal evolution of bed…
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Two case studies were studied in a high shear wet granulator using a hydrophobic API and a hydrophilic excipient An increase in granule growth was observed with an increase in percentage composition of the hydrophobic API Regime map analyses and granule characterization tests were performed…
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The present study aims to develop a mechanistic model to predict the performance of a fluid bed granulation process. Therefore, the behavior of the bed was investigated experimentally for various operating conditions. It was observed that the granule Loss on Drying and granule size are strongly…
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1 Granulation Technology Granulation technology is commonly used in the pharmaceutical industry during solid oral dosage form development, especially in tablet and capsule manufacturing (Parikh, 2010; Shanmugam, 2015). The process commonly is used for size enlargement, where small particles are…
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Hydroxypropyl methylcellulose (HPMC) is a frequently used matrix former for controlled release tablets. To adjust desired drug release kinetics, freely water-soluble lactose can be added. The aim of this study was to investigate the importance of the type of preparation technique of propranolol…
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05. March 2015 Background: Current treatment for adrenal insufficiency in neonates and infants is unsatisfactory as unlicensed adult formulations are used and the minimum unit dose available is a scored 5mg hydrocortisone tablet.  These are difficult to administer to neonates and…
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17. August 2017 For the development of this excipient for direct compression no chemical modification was applied. The enhanced functionality enabling a nearly zero order release was achieved by techniques such as physical mixing, high shear mixer granulation and spray drying.…
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Sugars and sweeteners are common ingredients in foods and also in pharmaceutical industries. They are soluble and sticky ingredients and their processing in granulators may be difficult since they can easily adhere to mixer walls or lead to uncontrolled granule growth. The purpose of this…
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