Granulation

Oral solid dosage (OSD) occupies a key position in the market of Chinese patent medicines and new traditional Chinese medicines. Processing route is the foundation for the research and development of traditional Chinese medicine OSDs. On the basis of prescriptions and preparation methods of 1 308…
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Introduction Granulation of powder blends is a commonly applied technique for pharmaceutical formulations which have no suitable flowability or compactability or are inhomogeneous with regards to the API content. Mainly wet granulation is applied3 and here, especially continuous twin-screw…
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Abstract Exposing the hydrated-soft-starch matrix of intact grain or reconstituted flour dough to a high-temperature-short-time (HTST) leads to rapid vapor generation that facilitates high-pressure build-up in its elastic matrix linked to large deformation and expansion. The expanded starch matrix…
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With DC Granules, Dr. Paul Lohmann produces a line that is ideally suitable for direct tableting for pharmaceutical applications. Granulation enlarges the particle size, converting fine or coarse powders into physically strong and larger granules with uniform shape, good flow property as well as…
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In this work, the feasibility of implementing a process analytical technology (PAT) platform consisting of Near Infrared Spectroscopy (NIR) and particle size distribution (PSD) analysis was evaluated for the prediction of granule downstream processability. A Design of Experiments-based calibration…
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The desired end product properties can make a difference when choosing between spray drying or spray granulation Both spray drying and fluid bed spray granulation can be used to convert liquid products into bulk materials. The most effective process will often be dictated by the desired properties…
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Press Release La Madeleine (France), 25th October 2023 – Roquette, a global leader in plant-based ingredients and leading provider of pharmaceutical and nutraceutical excipients, is pleased to announce the addition of three new excipient grades to its unmatched portfolio of solutions for moisture…
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ABSTRACT Objective: The study aims to compare the tableting qualities of isomalt and co-processed isomalt. Methodology: Co-processed isomalt prepared by melt granulation method evaluated for flow property, dilution potential, Kawakita plot, consolidation index, tabletability, Heckel plot and…
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Abstract Orally disintegrating tablets (ODTs) is a popular drug delivery system as they dissolve in the mouth, usually within seconds which enables easy medication for patients with problem swallowing. In this thesis properties of ODTs were compared when produced with direct compression of the…
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Abstract Lactose is an excipient used extensively for bulking, diluting, and molding active pharmaceutical ingredients in tablet manufacturing. Particularly, granulated lactose (GL) intended for direct powder compression has distinct properties due to differences in manufacturing methods. It…
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