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Granulation
Typical Physical Attributes of Microcrystalline Cellulose Dried by Spray, Spin Flash and Bulk Drier…
ABSTRACT
The solid dosage form is the easiest method of administering drugs for systemic effect. All dosages forms are made by two main components one is API and second is excipient. Excipient is present in bulk quantity and is required for binding the API. There are mainly two techniques uses for…
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The Guide to Formulating Oral Extended-Release Tablets
Extended-release tablets, also known as sustained-release, controlled-release, or time-release tablets, have become increasingly important in the healthcare sector due to their ability to maintain consistent drug levels in the body over a specific period. This drug delivery system provides various…
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Evaluation of tricalcium citrate as a direct compressible diluent using the SeDeM Expert Diagram…
ABSTRACT
Oral administration of medicine is one of the most common delivery routes still in use today. Various dosage forms are administered via the oral route including tablets, capsules, syrups, solutions and emulsions. Tablets constitute a large part of orally available dosage forms due to ease…
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A tabletability change classification system in supporting the tablet formulation design via the…
In this paper, the material library approach was used to uncover the pattern of tabletability change and related risk for tablet formulation design under the roll compaction and dry granulation (RCDG) process. 31 materials were fully characterized using 18 physical parameters and 9 compression…
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Effect of process parameters in high shear granulation on characteristics of a novel co-processed…
In this study, insights into the development and optimization of a co-processed excipient based on mesoporous silica are presented. The main advantage of such a material is that it is appropriate for direct tablet compression and has a sufficiently large specific surface area to be suitable for…
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A Machine Learning Approach to Qualitatively Evaluate Different Granulation Phases by Acoustic…
Wet granulation is a frequent process in the pharmaceutical industry. As a starting point for numerous dosage forms, the quality of the granulation not only affects subsequent production steps but also impacts the quality of the final product. It is thus crucial and economical to monitor this…
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Evaluating spray gelation and spray freeze drying as the granulation method to prepare oral tablets…
Amorphous drug nanoplex represents one of the most promising solubility enhancement strategies of poorly-soluble drugs. Solubility enhancement capability of nanoplex hitherto has been demonstrated for nanoplex suspension and lyophilized/spray-dried nanoplex, but not for its oral tablets. Using…
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AVICEL® PH LN – A Low Nitrite Microcrystalline Cellulose
Pharma Solutions at IFF provides you access to one of the broadest microcrystalline cellulose (MCC) portfolios in the industry. Backed by decades of innovation, and expertise, Avicel® PH offers a long history of manufacturing the highest-quality pharmaceutical grade MCC.
Our deep polymer…
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Study of direct compression coverage in view of design space – Ceolus UF grades
1. What is the design space?
The design space (DS) is a multidimensional combination and interaction of input variables (e.g., properties of raw materials) and process parameters that have been proven to ensure the quality of drug products. Operation within the DS is not considered a change,…
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Attribute transmission and effects of diluents and granulation liquids on granule properties and…
This study aims to examine (i) the effect of diluent types (lactose monohydrate, corn starch, and microcrystalline cellulose) and granulation liquids (20% polyvinylpyrrolidone K30, 65% alcohol, and dispersion containing 40% model drug– Pithecellobium clypearia Benth extracted powder) on granule…
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