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Granulation
Comparison of Ceolus™ Grades in Continuous Manufacturing (Wet Granulation) – Continuous…
1. Introduction
Until now, batch manufacturing has been the main mode of pharmaceutical manufacture: raw materials are input and processed in a stage of the process then removed for input and process in the next stage of the sequence. However, in recent years, manufacturers have explored…
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Kollicoat® Smartseal combines an effective taste-masking functionality with efficient processing
Kollicoat® Smartseal 30 D and Kollicoat® Smartseal 100 P can help formulators tackle challenges when handling bitter active ingredients. It offers superior protection from unpleasant drug taste for minitablets, pellets, particles, and granules used in orally disintegrating dosage forms, improving…
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Integrated continuous melt granulation-based powder-to-tablet line: process investigation and…
In the last decades, continuous manufacturing (CM) has become a research priority in the pharmaceutical industry. However, significantly fewer scientific researches address the investigation of integrated, continuous systems, a field that needs further exploration to facilitate the implementation of…
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Planetary roller melt granulation (PRMG) – A new continuous method for powder processing
Abstract
For the continuous operation of granulation, which is a standard unit operation in powder processing to modify the particle size, the use of twin-screw machines was established as standard method for wet and melt granulation over the last decade. A main characteristic for this technology…
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Deep Learning-Based Machine Vision System for Use in High-Shear Granulation
Aim
Develop a prototype machine vision system and evaluate feasibility of a deep learning-based image analysis approach for estimation of the state of granulation on the acquired granule bulk surface images.
Introduction
Despite many decades of research in granulation technology, the…
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Deep Learning-Based Machine Vision System for In-Line Monitoring of High-Shear Wet Granulation…
Aim
Develop a machine vision system for in-line monitoring of high-shear granulation processes to provide a more reliable and continuous solution for assessing the state of granulation.
Introduction
Granulation is critical for pharmaceutical production, but inherently complex and poorly…
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Comparison of Ceolus™ Grades – Continuous Manufacturing System “Granuformer® Gf-2050”
Comparison of Ceolus™ Grades in Continuous Manufacturing (Wet Granulation) - Continuous Manufacturing System “Granuformer® Gf-2050”
Introduction
Until now, batch manufacturing has been the main mode of pharmaceutical manufacture: raw materials are input and processed in a stage of the process then…
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Development of a New Age-Appropriate, Chewable Tablet of Mebendazole 500 mg for Preventive…
The aim of this study was to develop an age-appropriate tablet of mebendazole 500 mg to be used in large donation programs by the World Health Organization (WHO) for preventive chemotherapy of soil-transmitted helminth (STH) infections in pre-school and school-age children living in tropical and…
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Control oriented modeling of twin-screw granulation in the ConsiGma-25 production plant
ConsiGmaTM-25 is a continuous production plant integrating a twin-screw granulation, fluid bed drying, granule conditioning, and a tableting unit. The particle size distribution (PSD), active pharmaceutical ingredient (API) content, and liquid content of wet granules after twin-screw granulation…
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Role of additives in starch-based edible films and coating: A review with current knowledge
Edible films and coating provide a potentially effective method for preserving fresh food products by reducing moisture loss, regulating respiration rate, improving surface smoothness, and or preventing microbial growth during their storage. Concurrently, starch has proven for its inexpensive,…
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