Granulation

Tablets are the favored dosage form for numerous active pharmaceutical ingredients, among others because they are easy to take, ensure safe dosing and allow cost-effective production on a large scale. This dosage form is also frequently chosen for the administration of viable probiotic …
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See the sixth issue of Fuji Chemical Industries Technical Newsletter: Directly compressible excipient system for fast-Disintegrating oral tablets*, F-MELT® formulations are designed with a focus on three important characteristics of ODTs: tablet hardness, mouthfeel, and acceptable oral…
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The aim of this feasibility study was to investigate the possibility of producing industrial-scale relevant, robust, high drug-loaded (90.9%, w/w) 100 mg dose immediate-release tablets of isoniazid and simultaneously meet the biowaiver requirements. With an understanding of the real-life…
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A recently developed process analytical technology (PAT) using artificial intelligence to form the framework of its model, combining frequency-domain acoustic emissions (AE) and elastic impact mechanics to accurately predict complex particle size distributions (PSD) in real-time. This model was…
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The maximal amount of drug contained in a minitablet is limited. To reduce the total number of minitablets in a single dose, high drug load minitablets can be prepared from high drug load feed powders by various pharmaceutical processing techniques. Few researchers have however examined the…
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ABSTRACT Background: As the pharmaceutical industry shifts to a patient-oriented approach, pharmaceutical education has fairly garnered increasing attention from educators, so that the teaching course centered on pharmaceutical excipients is becoming more and more popular. Purpose: The purpose…
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A practice based approach for the scale-up of fluid bed granulation in the context of drug product  development is presented and evaluated in this work in the context of clinical drug product manufacturing development. The approach is based on using a scale independent parameter, the evaporation…
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Speed. Precision. Patient-centricity. Roquette´s PEARLITOL® 200 GT granulated mannitol is here to revolutionize direct compression. Realize the potential of novel drug formats with smaller, harder tablets produced at unprecedented speeds – without compromising on quality. PEARLITOL® 200 GT…
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The influence of localization (intragranular, split or extragranular) of three superdisintegrants (croscarmellose sodium, crospovidone, sodium starch glycolate) on granules and tablets after twin-screw granulation was studied. The aim was to find a suitable disintegrant type and disintegrant…
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SEE PEARLITOL® CR-H Roquette´s new, industry-first mannitol and hydroxypropyl methylcellulose (HPMC) blend, designed for controlled release drug formulation. Leave behind wet granulation, lengthy drying times and limited flowability and unlock the potential of direct compression to create…
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