Granulation

The administration of living microorganisms is of special interest, with regard to probiotic microorganisms providing health benefits to the patient. Effective dosage forms require the preservation of microbial viability until administration. Storage stability can be improved by drying, and the…
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High shear wet granulation and tableting (HSWG-T) are complex pharmaceutical processes, which makes tablet quality be influenced by many variables including raw material attributes, process variables, and intermediate granule properties. To achieve the desired final quality of tablets and improve…
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The STYL’One Nano is the revolutionary benchtop R&D tablet press for demanding formulation scientists. Characterize your API and develop your single layer formulation with only a few grams of powder! Technical highlights: ✔ Benchtop model compact and mobile with a small footprint ✔ Driven…
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Although previous research demonstrated improved flowability, packing, fluidization, etc. of individual powders via nanoparticle dry coating, none considered its impact on very low drug loaded blends. Here, fine ibuprofen at 1, 3, and 5 wt% drug loadings (DL) was used in multi-component blends to…
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Compressed mini-tablets in sachets or capsules are an increasingly prevalent oral solid dosage form for pediatric products. While resembling adult tablets, additional care is required to control weight and potency (blend uniformity) variation due to their small size (≤2.5 mm average diameter).…
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Population balance models (PBMs) have been widely studied for the simulation of continuous twin-screw wet granulation. Due to the limited data availability and computational efforts, one-dimensional PBM is the most popular application to the pharmaceutical industry. While multi-dimensional PBMs can…
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The objective of this study was to prepare agglomerated isomalt by using the melt granulation process. This method involved the use of 99.5% of isomalt with the meltable binder glyceryl monostearate in a concentration of 0.5%. Glyceryl monostearate has a melting point of 50°C to 55°C, therefore,…
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A fine, hygroscopic, and poorly flowable probiotic powder encapsulating Lactobacillus rhamnosus GG (LGG) was granulated using a high-shear granulation process, wherein a small amount of water (4%, w/w) was used for moisture-activation with or without 10% (w/w) resistant maltodextrin (RM). The…
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Are you experiencing capping issues? Are you facing edge chipping? Compactability challenge? We offer a problem solver! - CEOLUS™ MCC CEOLUS™KG – High compactible Microcrystalline Cellulose Benefits Faciliate high dosage formulation Lower tablet friability Realize low pressure…
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This paper presents surrogate models of dissolution behavior to identify the critical input parameters in tablet manufacturing processes. Dissolution behavior is a critical quality attribute, and is defined as the time profile of fraction of dissolved active pharmaceutical ingredients in a solvent…
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