Hot-melt coating

Abstract The hot-melt coating process is widely used in the food and pharmaceutical industries. Its purpose of use is very diverse and includes, among other things, changing the functional properties of the particle surfaces, forming a protective layer or influencing the release rate of the…
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Non-compliance, dosing inaccuracy, choking risk, flavour, and instability, are some of the issues associated with paediatric, oral dosage forms — tablets, capsules, solutions, and suspensions. Orally disintegrating drug carriers, a dosage form with growing interest, are thought to overcome several…
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Use of high melting point solid vegetable oils in encapsulation processes Introduction to encapsulation Encapsulation relates to technologies that enable the incorporation of a compound into individualized small particles. Depending on the process applied, these particles can have…
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YOUR FORMULATION CHALLENGE - IOI Oleo SOLUTIONS According to the Biopharmaceutical Classification System (BCS), more than 70% of the APIs used in pharmaceutical preparations are difficult to formulate due to poor solubility and/or permeabilities, and the majority of drug candidates have…
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In order to achieve a defined product behavior, the coating of particulate solids is an often used process in the food, chemical, and pharmaceutical industries. The wetting behavior affects the coating quality associated with hot-melt coating (HMC) considerably more than the quality associated with…
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Recent industry trends show many pharmaceutical manufacturers are creating drugs with greater degrees of lipophilicity, higher molecular weight, greater physical form complexity and lower aqueous solubility. Unfortunately, these characteristics often produce poorly soluble drugs, which means the…
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Hot melt coating (HMC) of an active pharmaceutical ingredient (API) powder with lipid-based excipients is an innovative method for manufacturing patient-convenient dosage forms. However, drug release instability is still its main industrial challenge. The correlation between the unstable…
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What is the ExciPerience? ExciPerience 2021 was the new virtual event around every aspect of pharmaceutical excipients. ExciPerience covered all areas from basic or advanced research and formulation to manufacturing and regulatory. It was the intersection between all the different perspectives…
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Hot-melt coating (HMC) as a solvent-free technology grants faster and more economic coating processes with reduced risk of dissolving the drug during the process. Moreover, traditional coating equipment can be modified to enable the HMC process. Despite the indubitable advantages and…
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The use of amorphous drug delivery systems is an attractive approach to improve the bioavailability of low molecular weight drug candidates that suffer from poor aqueous solubility. However, the pharmaceutical performance of many neat amorphous drugs is compromised by their tendency for…
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