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Hot-melt extrusion
3D printing of amorphous solid dispersions: A comparison of fused deposition modeling and…
Nowadays, a high number of pipeline drugs are poorly soluble and require solubility enhancement by e.g., manufacturing of amorphous solid dispersion. Pharmaceutical 3D printing has great potential in producing amorphous solid oral dosage forms. However, 3D printing techniques differ greatly in terms…
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Hot Melt Extrusion as an Effective Process in the Development of Mucoadhesive Tablets Containing…
Hot Melt Extrusion (HME) technology was developed to obtain blends containing lyophilized Scutellariae baicalensis root extract and chitosan in order to improve the rheological properties of the obtained blends, including tableting and compressibility properties. (Hydroxypropyl)methyl cellulose…
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Hot Melt Extruded Posaconazole-Based Amorphous Solid Dispersions—The Effect of Different Types of…
Four model polymers, representing (i) amorphous homopolymers (Kollidon K30, K30), (ii) amorphous heteropolymers (Kollidon VA64, KVA), (iii) semi-crystalline homopolymers (Parteck MXP, PXP), and (iv) semi-crystalline heteropolymers (Kollicoat IR, KIR), were examined for their effectiveness in…
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3D Printing for Personalised Medicines: Implications for Policy and Practice
The current healthcare dynamic has shifted from one-size-fits-all to patient-centred care, with our increased understanding of pharmacokinetics and pharmacogenomics demanding a switch to more individualised therapies. As the pharmaceutical industry remains yet to succumb to the push of a…
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Updates on applications of low-viscosity grade Hydroxypropyl methylcellulose in coprocessing for…
Hydroxypropyl methylcellulose (HPMC) is an important polymeric excipient. Its versatility in terms of molecular weights and viscosity grades is the basis for its wide and successful application in the pharmaceutical industry. Low viscosity grades of HPMC (like E3 and E5) have been used as physical…
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Development of Mefenamic Acid-Soluplus® amorphous dispersions via hot melt extrusion and in silico…
The objective of this study was to increase the solubility of Mefenamic Acid (MA), a BCS class II drug by formulating amorphous solid dispersions via Hot-Melt Extrusion. The extrudates were prepared at different drug to polymer ratios and characterised by standard analytical techniques. Dissolution…
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Controlled delivery via hot-melt extrusion: A focus on non-biodegradable carriers for non-oral…
Hot-melt extrusion (HME) has an esteemed place in the pharmaceutical industry with significant applications and advancements spreading over 30 years of development. Currently, the choice of matrix excipients is vast, expanding from all different kinds of synthetic polymers to natural carriers.…
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New and Novel Excipients 2022
The pharmaceutical industry needs innovative, new and novel excipients solutions to support the developments in next generation therapeutics, new manufacturing concepts (eg. continuous manufacturing, 3Dprinting, etc.), drug delivery and API challenges such as solubility and permeability just to…
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Micro-Scale Vacuum Compression Molding as a Predictive Screening Tool of Protein Integrity for…
Hot-melt extrusion (HME) is used for the production of solid protein formulations mainly for two reasons: increased protein stability in solid state and/or long-term release systems (e.g., protein-loaded implants). However, HME requires considerable amounts of material even at small-scale (>2 g…
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Enhancement of itraconazole solubility and release by hot-melt extrusion with Soluplus®
Formulation of poorly water-soluble drugs is a significant challenge in the development of oral solid dosage forms. The objective was to investigate the effect of hot-melt extrusion process and formulation variables on the solid state, solubility and release of an ionizable poorly soluble drug,…
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