Browsing Category
Hot-melt extrusion
From Screening to Downstreaming – 4th Seminar on Amorphous Solid Dispersion
See the 4th Seminar on Amorphous Solid Dispersion.
As technology provider in the field of ASD, Shin-Etsu together with the partners Alexanderwerk, Frewitt, PROCEPT and Thermo Fisher Scientific, will share latest insights of ASD development steps ranging from initial screening phase up to downstream…
Read More...
Read More...
Downstream processing of amorphous solid dispersions into tablets
Amorphous solid dispersions have gained tremendous attention as a commercially viable solubility enhancement technique for poorly water-soluble drugs. However, poor drug loading associated with poor drug-polymer miscibility is a major challenge in the downstream processing of ASDs. While many…
Read More...
Read More...
Enhancing the oral drug delivery through hot melt extrusion techniques
Hot melt extrusion has been developed as a fresh technique for taste masking, in recent years. This method provides many aids as compared to traditional methods like avoiding the use of solvents, continuous manufacturing, ease to scale up, and adaptability to meet the goals of FDA for quality…
Read More...
Read More...
Hybrid Manufacturing of Oral Solid Dosage Forms via Overprinting of Injection-Molded Tablet…
Since 3D printing allows for patient-specific dosage forms, it has become a major focus in pharmaceutical research. However, it is difficult to scale up drug product manufacturing. Injection molding has been used in conjunction with hot-melt extrusion to mass produce drug products, but making…
Read More...
Read More...
Influence of PLGA End Groups on the Release Profile of Dexamethasone from Ocular Implants
The present study deals with the development of dexamethasone (DM)-loaded implants using ester end-capped Resomer RG 502 poly(lactic acid-co-glycolic acid) (PLGA) (502), acid end-capped Resomer RG 502H PLGA (502H), and a 502H:502 mixture (3:1) via hot melt extrusion (HME). The prepared intravitreal…
Read More...
Read More...
The applications of machine learning to predict the forming of chemically stable amorphous solid…
Amorphous solid dispersion (ASD) is one of the most important strategies to improve the solubility and dissolution rate of poorly water-soluble drugs. As a widely used technique to prepare ASDs, hot-melt extrusion (HME) provides various benefits, including a solvent-free process, continuous…
Read More...
Read More...
Development of multifunctional drug delivery system via hot-melt extrusion paired with fused…
The model of core–shell structured tablets is gaining increased interest due to its advantages in controlled-release and combinational drug delivery. Through the encapsulation of the drug by the outer shell, this model exhibits huge potential for reduced administration frequency, improved…
Read More...
Read More...
Extrusion for pharma applications: An update
This paper aims to give an overview of our current research and development on hot-melt extrusion (HME) for pharmaceutical formulation and drug delivery. Unfortunately, a large percentage of marketed drugs (40%) and those in the development pipeline (90%) are poorly water soluble.
We use a few…
Read More...
Read More...
Drop-on-powder 3D printing of amorphous high dose oral dosage forms: Process development,…
Drop-on-powder 3D printing is able to produce highly drug loaded solid oral dosage forms. However, this technique is mainly limited to well soluble drugs. The majority of pipeline compounds is poorly soluble, though, and requires solubility enhancement, e.g., via formation of amorphous solid…
Read More...
Read More...
Advances in Formulation and Manufacturing Strategies for the Delivery of Therapeutic Proteins and…
Therapeutic proteins and peptides (TPPs) are increasingly favoured above small drug molecules due to their high specificity to the site of action and reduced adverse effects resulting in increased use of these agents for medical treatments and therapies. Consequently, there is a need to formulate…
Read More...
Read More...