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Hot-melt extrusion
Formulation Development and In Vitro–Ex Vivo Characterization of Hot-Melt Extruded Ciprofloxacin…
This study developed, optimized, characterized, and evaluated bioadhesive, hot-melt extruded (HME), extended-release ocular inserts containing ciprofloxacin hydrochloride (CIP-HCL) to improve the therapeutic outcomes of ocular bacterial infections. The inserts were fabricated with FDA-approved…
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Novel Approach to Pharmaceutical 3D-Printing Omitting the Need for Filament—Investigation of…
The utilized 3D printhead employs an innovative hot-melt extrusion (HME) design approach being fed by drug-loaded polymer granules and making filament strands obsolete. Oscillatory rheology is a key tool for understanding the behavior of a polymer melt in extrusion processes. In this study, small…
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Buccal films: A review of therapeutic opportunities, formulations & relevant evaluation…
The potential of the mucoadhesive film technology is hard to ignore, owing to perceived superior patient acceptability versus buccal tablets, and significant therapeutic opportunities compared to conventional oral drug delivery systems, especially for those who suffer from dysphagia. In spite of…
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Days or Centuries? – Predicting the Shelf-Life of ASDS
PURPOSE
Amorphous solid dispersions (ASDs) are a state-of-the-art enabling formulation technique for poorly water-soluble drugs. Drug recrystallization in the polymer matrix highly unwanted: marks end of shelf life of such a formulation.
Overcoming the poorly understood drug recrystallization…
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Effect of Precirol ATO5 concentration and twin-screw melt granulation temperature on the physical…
SUMMARY
The pharmaceutical industry has a growing interest in continuous manufacturing, particularly for high-volume dosage forms such as solid oral tablets. This is driven by the obvious benefits such as small footprint, batch size flexibility, the relative simplicity of scale-up and process…
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Tunable Drug Release from Fused Deposition Modelling (FDM) 3D-Printed Tablets Fabricated Using a…
Three-dimensional (3D) printing is proving to be a pivotal technology for developing personalized dosage forms with bench to bedside feasibility. Fused deposition modelling (FDM) 3D printing has emerged as the most used technique wherein molten drug-loaded polymer filaments are deposited…
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Hot-Melt Extrusion of the Thermo-Sensitive Peptidomimetic Drug Enalapril Maleate
The aim of this research was the production of extrudates for the treatment of hypertension and heart failure and the investigation of the degradation of the peptidomimetic drug enalapril maleate (EM) during hot-melt extrusion (HME). A fast HPLC method was developed to quantify enalapril maleate and…
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Existing and emerging mitigation strategies for the prevention of accidental overdose from oral…
Misadventure with pharmaceutical oral medication has been on the rise, with the opioid crisis playing a major part. Drug overdose related to opioids has become such an issue, that it has been labelled a worldwide crisis. This review explores the mitigation strategies currently in place to prevent…
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New and Novel Excipients
The pharmaceutical industry needs innovative, new and novel excipients solutions to support the developments in next generation therapeutics, new manufacturing concepts (eg. continuous manufacturing, 3Dprinting, etc.), drug delivery and API challenges such as solubility and permeability just to…
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Continuous Processing of Micropellets via Hot-Melt Extrusion
Microparticulate drug delivery systems, e.g., micropellets (MPs), are used in a variety of pharmaceutical formulations such as suspensions, injectable systems, and capsules. MPs are currently manufactured mainly via batch, solvent-based processes, e.g., spray-drying and solvent…
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