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Hot-melt extrusion
Formulation performance window for manufacturing cellulose-based sustained-release mini-matrices of…
The aim of the proposed work was to develop robust hot-melt extrusion (HME) process for fabricating sustained-release mini-matrices (pellets) of a highly water-soluble drug, tramadol hydrochloride. The current work was designed to identify a formulation window with target functional performances…
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Design, Preparation and In Vitro Evaluation of Core–Shell Fused Deposition Modelling 3D-Printed…
The aim of the study was to investigate core–shell pulsatile tablets by combining the advantages of FDM 3D printing and traditional pharmaceutical technology, which are suitable for a patient’s individual medication and chronopathology. The tablets were designed and prepared with the commercial…
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Solubility enhancement – Transform insoluble drugs into stable and efficient formulations
Recent industry trends show many pharmaceutical manufacturers are creating drugs with greater degrees of lipophilicity, higher molecular weight, greater physical form complexity and lower aqueous solubility. Unfortunately, these characteristics often produce poorly soluble drugs, which means the…
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3D printing of pharmaceutical oral solid dosage forms by fused deposition: the enhancement of…
3D printing (3DP) by fused deposition modelling (FDM) is one of the most extensively developed methods in additive manufacturing. Optimizing printability by improving feedability, nozzle extrusion, and layer deposition is crucial for manufacturing solid oral dosage forms with desirable properties.…
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FDM 3D-Printed Sustained-Release Gastric-Floating Verapamil Hydrochloride Formulations with…
The aim of this work was to design and fabricate fused deposition modeling (FDM) 3D-printed sustained-release gastric-floating formulations with different shapes (cylinder, capsule and hemisphere) and infill percentages (0% and 15%), and to investigate the influence of shape and infill percentage on…
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Factors Influencing the Crystallization-Onset Time of Metastable ASDs
In formulation development, amorphous solid dispersions (ASD) are considered to improve the bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs). However, the crystallization of APIs often limits long-term stability and thus the shelf life of ASDs. It has already been…
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Precise Dosing of Pramipexole for Low-Dosed Filament Production by Hot Melt Extrusion Applying…
The aim of this research was the production of low-dosed filaments via hot-melt extrusion (HME) with the model drug pramipexole for the treatment of Parkinson’s disease. The active pharmaceutical ingredient (API) and one of the polymers polyvinyl alcohol (PVA) or basic butylated methacrylate…
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Hot-melt extruded hydroxypropyl methylcellulose acetate succinate based amorphous solid dispersions:…
Nucleation inhibition and maintenance of drug supersaturation over a prolonged period are desirable for improving oral absorption of amorphous solid dispersions. The present study investigates the impact of binary and ternary amorphous solid dispersions on the supersaturation kinetics of nifedipine…
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Hot-melt extrudability of amorphous solid dispersions of flubendazole-copovidone: An exploratory…
The FDA-approved anthelmintic flubendazole has shown potential to be repositioned to treat cancer and dry macular degeneration; however, its poor water solubility limits its use. Amorphous solid dispersions may overcome this challenge, but the balance of excipients may impact the preparation method…
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Comparison of Hydroxypropylcellulose and Hot-Melt Extrudable Hypromellose in Twin-Screw Melt…
High-molecular-weight hypromellose (HPMC) and hydroxypropyl cellulose (HPC) are widely known, extended-release polymers. Conventional high-molecular-weight HPMCs are preferred in extended-release applications but not widely used in twin-screw melt granulation due to processability difficulties at…
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