Browsing Category
Hot-melt extrusion
3D-Printed Coating of Extended-Release Matrix Tablets Effective Tool for Prevention of…
Tablets used for extended drug release commonly contain large amounts of drugs. The corresponding drug release mechanism thus has to be well-known and invariable under numerous conditions in order to prevent any uncontrolled drug release. Particularly important is the stability and invariability of…
Read More...
Read More...
Application of TPGS as an efflux inhibitor and a plasticizer in baicalein solid dispersion
The oral bioavailability and efficacy of baicalein is dramatically limited by its low solubility and effect of efflux. In our study, we chose PVP-VA64 as a carrier and TPGS as a plasticizer and efflux inhibitor to prepare a solid dispersion of baicalein using hot-melt extrusion technology to improve…
Read More...
Read More...
Quality of FDM 3D Printed Medicines for Pediatrics: Considerations for Formulation Development,…
3d printing is capable of providing dose individualization for pediatric medicines and translating the precision medicine approach into practical application. In pediatrics, dose individualization and preparation of small dosage forms is a requirement for successful therapy, which is frequently not…
Read More...
Read More...
Application of TPGS as an efflux inhibitor and a plasticizer in baicalein solid dispersion
The oral bioavailability and efficacy of baicalein is dramatically limited by its low solubility and effect of efflux. In our study, we chose PVP-VA 64 as a carrier and TPGS as a plasticizer and efflux inhibitor to prepare a solid dispersion of baicalein using hot-melt extrusion technology to…
Read More...
Read More...
Enhanced Supersaturation via Fusion-Assisted Amorphization during FDM 3D Printing of Crystalline…
Filaments loaded with griseofulvin (GF), a model poorly water-soluble drug, were prepared and used for 3D printing via fused deposition modeling (FDM). GF was selected due to its high melting temperature, enabling lower temperature hot-melt extrusion (HME) keeping GF largely crystalline in the…
Read More...
Read More...
Compression of amorphous solid dispersions prepared by hot-melt extrusion, spray drying and vacuum…
The present study explored vacuum drum drying (VDD) as an alternative technology for amorphous solid dispersions (ASDs) manufacture compared to hot-melt extrusion (HME) and spray drying (SD) focusing on downstream processability (powder properties, compression behavior and tablet performance).…
Read More...
Read More...
Can filaments, pellets and powder be used as feedstock to produce highly drug-loaded ethylene-vinyl…
Highlights
• The mechanical and rheological properties are limiting steps for FFF.
• Increasing the VA content showed lower buckling stress, elastic and flexural modulus.
• The inadequate flow during FFF was due to the viscosity variation during extrusion.
• DEAM showed formulation…
Read More...
Read More...
Exploration of theoretical and practical evaluation on Kollidon®SR matrix mediated amorphous…
The selection of an appropriate polymer for the preparation of amorphous solid dispersions via hot-melt extrusion (HME) deals with the study of various solid-state properties of drugs and polymers. Hence, before going to HME, it is necessary to have appropriate knowledge of drug-polymer miscibility,…
Read More...
Read More...
Development of a 3D-Printed Dosing Platform to Aid in Zolpidem Withdrawal Therapy
The long-term use of benzodiazepine receptor agonists (BZRAs) is associated with multiple side effects, such as increased sedation, hangover or an elevated risk of dependency and abuse. Unfortunately, the long-term use of BZRAs is reaching worrying intake rates, and therefore, the need for action is…
Read More...
Read More...
Dry Powder Mixing Is Feasible in Continuous Twin Screw Extruder: Towards Lean Extrusion Process for…
Using discrete element method (DEM) modeling and near-infrared (NIR) spectroscopy, the feasibility of powder mixing in the initial pre-melting zones of a twin screw extruder using two independent feeders was studied. Previous work in the pharmaceutical and food industry has focused on mixing when…
Read More...
Read More...