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Hot-melt extrusion
Enhance the solubility of poorly soluble drugs with AFFINISOL™
Looking to enhance the solubility of poorly soluble drugs?
Consider AFFINISOL™, a water-soluble polymer that optimizes solubility enhancement by maintaining stable solid dispersions and inhibiting API crystallization.
It’s been specifically designed for generating solid dispersions via…
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Study of solid-state transitions and its impact on solubility and stability of Repaglinide
The aim of this research was to study the impact of melting and quenching approach on solid-state characteristics of amorphous dispersion and its impact on dissolution and solubility of Repaglinide, a BCS Class II drug. Solid dispersions of Repaglinide were prepared separately by quench cooling…
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Polymers for Extrusion-Based 3D Printing of Pharmaceuticals: A Holistic Materials–Process…
Three dimensional (3D) printing as an advanced manufacturing technology is progressing to be established in the pharmaceutical industry to overcome the traditional manufacturing regime of 'one size fits for all'. Using 3D printing, it is possible to design and develop complex dosage forms that can…
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Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in…
Eudragit® polymers are polymethacrylates highly used in pharmaceutics for the development of modified drug delivery systems. They are widely known due to their versatility with regards to chemical composition, solubility, and swelling properties. Moreover, Eudragit polymers are thermoplastic, and…
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Pharmaceutical application and development of fixed-dose combination: dosage form review
Background
Fixed dose combination (FDC) products are common in the treatment of various disease such as hypertension, diabetes, HIV and HCV, Pain, Respiratory disease for improving therapeutic efficacy and tolerability. They make it possible to combine more than two drug molecules with optimal…
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Solid dispersions: improving drug performance through tablet micro-structure design
Purpose Solid dispersions formulations manufactured by Hot-Melt-Extrusion (HME) have shown to improve drug release for BCS class II drugs, such as Mefenamic acid (MFA). Drug release for MFA is highly dependent on particle size. Commercially available MFA capsules have shown high variability in their…
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Chrono modulated multiple unit particulate systems (MUPS) via a continuous hot melt double extrusion…
The current study is aimed at the development of chrono modulated multiple unit particulate systems (MUPS) of nifedipine (ND) by a continuous double extrusion process. ND, a poorly soluble drug, was formulated into an amorphous solid dispersion (ASD) to improve its solubility. Further, the ASD was…
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Injection-molded capsule bodies and caps based on polymer blends for controlled drug delivery
A variety of polymer:polymer blends was used to prepare hot melt extrudates and empty capsules (bodies and caps) by injection molding using a benchtop extruder (Babyplast). Kollidon SR:inulin and Carbothane:inulin blends were investigated. The impact of the blend ratio on the water uptake and dry…
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Processing Impact on In Vitro and In Vivo Performance of Solid Dispersions—A Comparison between…
Presently, a large number of drug molecules in development are BCS class II or IV compounds with poor aqueous solubility. Various novel solubilization techniques have been used to enhance drug solubility. Among them, amorphous solid dispersions (ASD), which convert a crystalline drug into an…
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Recent and Relevant Methodology in the Advancement of Solid Dispersion
Most of the promising drugs in development channels are poorly water-soluble drugs which limit formulation approaches, clinical application because of their low dissolution and bioavailability. And the major current challenges of the pharmaceutical industry are apropos strategies that improve the…
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