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Hot-melt extrusion
Theoretical and experimental validation of praziquantel with different polymers for selection of an…
The selection of an appropriate matrix for the preparation of amorphous extrudate in hot-melt extrusion (HME) deals with the study of various solid-state properties of drugs and polymers. Therefore, it is necessary to have an appropriate knowledge of drug-polymer miscibility, the interaction between…
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Application of near-infrared spectroscopy in detecting residual crystallinity in carbamazepine –…
Amorphous solid dispersions can improve the solubility and dissolution rate of poorly soluble drugs. However, residual crystallinity can adversely affect the dissolution in formulations design to be in amorphous state. This study aimed to develop near-infrared spectroscopy (NIRS) as a potential…
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3D Printed Intragastric Floating and Sustained-release Tablets with Air Chambers
This work aimed to use hot-melt extrusion (HME) and dual fused deposition modeling (FDM) 3D printing technology to develop a novel intragastric floating and sustained-release drug delivery system. The intragastric floating and sustained-release tablet was engineered by employing hydroxypropyl…
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Tuning of Paroxetine 3D-Printable Formulations for Fused Deposition Modelling
This work reports the preliminary development of paroxetine-containing formulations amenable to hot-melt extrusion coupled to fused deposition modelling-based 3D printing. Polymeric matrices were used alone, or added with processing enhancers (e.g., plasticizer and filler). The polymeric formulation…
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Direct Powder Extrusion of Paracetamol Loaded Mixtures for 3D Printed Pharmaceutics for Personalized…
Three-dimensional printed drug development is nowadays an active area in the pharmaceutical industry, where the search for an appropriate edible carrier that permits the thermal processing of the mixture at temperature levels that are safe for the drug is an important field of study. Here, potato…
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Role of release modifiers to modulate drug release from fused deposition modelling (FDM) 3D printed…
Although hot melt extrusion (HME) has been used in combination with fused deposition modelling (FDM) three-dimensional printing (3DP), suitable feedstock materials such as polymeric filaments with optimum properties are still limited. In this study, various release modifying excipients, namely,…
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Effect of pH modifiers on the solubility, dissolution rate, and stability of telmisartan solid…
The aim of the current study was to investigate the dual effect of an amorphous solid dispersion generated by hot melt extrusion and the addition of pH modifiers on the solubility and stability of telmisartan. Hydroxypropyl methylcellulose acetate succinate L grade was used as a polymeric carrier…
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Webinar Recording: Hot Melt Extrusion (HME) with Shin-Etsu, Leistritz and the St. Johns University
Hot Melt Extrusion is a well established technology used in ASDs. Besides the advantage of being a solvent free method some attributes of the API and polymer have to be considered like glass transition temperature and decomposition temperature.
Shin-Etsu, Leistritz, and Prof. Serajuddin from St.…
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Improving the Bioavailability of Challenging APIs using Hot Melt Extrusion with Polyvinyl Alcohol
New molecular entities (NMEs) are becoming larger and more lipophilic and, as a result, less soluble. While approximately 40% of active pharmaceutical ingredients (APIs) currently on the market show poor solubility, it is estimated that between 60 and 90% of compounds in development have solubility…
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Solid Dispersion as a Technical Solution to Boost the Dissolution Rate and Bioavailability of Poorly…
Solid dispersion (SD) is one of the oldest and widely utilized techniques to improve the solubility of slowly dissolving drugs. A variety of pharmaceutically compatible additives using different emerging technology is used for preparing SDs. Multiple approaches were designed to prepare SDs by such…
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